Results 71 to 80 of about 50,222 (210)

Physiological media and oxygen levels modulate cancer hallmarks in cultured breast cancer cells

The FEBS Journal, EarlyView.
MCF7 breast cancer cells were cultured in standard conditions (18% O2 and DMEM) and physiological conditions (5% O2 and Plasmax, a medium modeled after the human plasma metabolome). A combined transcriptomic and proteomic approach was used to identify gene expression signatures at the mRNA and protein levels upstream of functional enrichment analyses ...
Jacob E. Wiebe, Ricardo Alva, Fereshteh Moradi, Sarah Alderman, Ping Liang, Jeffrey A. Stuart   +5 more
wiley   +1 more source

A randomized placebo controlled trial of Mitomycin - C in surgical outcome of primary endoscopic dacryocystorhinostomy [PDF]

Al Ameen Journal of Medical Sciences, 2013
Objective: To compare the patency of the stoma and relief of epiphora after endoscopic dacrocystorjinostomy (EnDCR) surgery with Mitomycin C and Placebo in cases of chronic dacrocystitis secondary to primary post saccal stenosis.
A.S. Harugop, B.K. Rekha, R.S. Mudhol, N.D. Zingade, S.M. Hugar, A.T. Das, M. Maheswaran   +6 more
doaj  

Cytotoxicity and Characteristics of Mitomycin C

Ophthalmic Research, 2009
In order to evaluate the cytotoxicity of mitomycin C (MMC), the effects of MMC on cell viability, cell cycle and cell surface structure were studied using Chang’s cultured human conjunctival cells. A 4- or 2-min exposure to MMC at concentrations ranging from 0.002 to 0.04% decreased the cell viability. The cell number was remarkably reduced by exposure
T, Murayama, N, Takahashi, N, Ikoma
openaire   +2 more sources

Context‐Dependent Regulation of Epithelial Cell Behaviour by Palatal Connective Tissue Graft‐Derived Fibroblasts via EGF and HB‐EGF Signalling

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To investigate how human palatal fibroblasts (HPFs) from anterior (A) or posterior (P) subepithelial connective tissue grafts (CTGs) regulate oral epithelial cell behaviour, focusing on epidermal growth factor (EGF) and heparin‐binding EGF‐like growth factor (HB‐EGF).
Xiaoqing Song, Cristina Nica, Alexandra Stähli, Anton Sculean, Maria B. Asparuhova   +4 more
wiley   +1 more source

Inhibition of P‐glycoprotein using photoimmunotherapy in peritoneal metastasis mouse model

Photochemistry and Photobiology, EarlyView.
Photoimmunotherapy (PIT) using photoimmunoconjugates (PICs) can inhibit the function of the ATP‐binding cassette (ABC) transporter P‐glycoprotein (P‐gp) in a mouse model of peritoneal carcinomatosis. Sterile‐filtered PIC was administered in vivo via intraperitoneal (IP) injection 20 days after IP tumor cell implantation of P‐gp‐overexpressing NCI/ADR ...
Kaitlyn A. Moore, Brian Schnoor, Kathryn L. McNaughton, Idrisa Rahman, Benjamin D. Powers, Dana M. Roque, Huang‐Chiao Huang   +6 more
wiley   +1 more source

Vision outcomes in dogs with primary glaucoma surgically treated with lensectomy and endolaser cyclophotocoagulation after an Ahmed valve gonioimplantation failure

Veterinary Ophthalmology, Volume 28, Issue 2, Page 207-217, March 2025.
Abstract Objective The aim of this study was to retrospectively evaluate vision outcomes of dogs with primary angle closure glaucoma (PACG) that underwent Ahmed valve gonioimplantation (AVG) followed by lensectomy and endolaser cyclophotocoagulation (ECP) with or without bleb resection after AVG failure.
Bactelius Turicea, Christian L. Munevar, Sydney G. Edwards, Lana L. Linton   +3 more
wiley   +1 more source

Delayed Epithelial Healing with Corneal Edema and Haze After Photorefractive Keratectomy Using Intraoperative Mitomycin C

International Medical Case Reports Journal, 2021
Majid Moshirfar,1– 3 William B West Jr,4 Dallin C Milner,5 Shannon E McCabe,1 Yasmyne C Ronquillo,1 Phillip C Hoopes1 1Hoopes Vision Research Center, Hoopes Vision, Draper, UT, 84020, USA; 2John A. Moran Eye Center, Department of Ophthalmology and Visual
Moshirfar M, West WB Jr, Milner DC, McCabe SE, Ronquillo YC, Hoopes PC   +5 more
doaj  

Preclinical and Toxicology Studies of LPM7100328, a Novel Oral GnRH Antagonist

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT LPM7100328 is a novel oral GnRH antagonist being developed for the prevention of premature luteinizing hormone (LH) surges in women undergoing controlled ovarian stimulation. The studies presented herein reported assessment of safety in favor of human clinical trials.
Yao Wang, Junxian Zhao, Fangxia Zou, Wanglin Jiang, Jianzhao Zhang, Pengfei Yu, Liang Ye, Xiaolin Sun, Chunmei Li, Jingwei Tian   +9 more
wiley   +1 more source

INtraVESical immunoTherapy (INVEST) prior to radical cystectomy for bladder cancer: trial protocol

BJU International, Volume 138, Issue 4, Page 607-619, October 2026.
Background High‐risk non‐muscle‐invasive bladder cancer (HRNMIBC) has a variable prognosis, managed predominantly by local surgical resection and intravesical Bacillus Calmette–Guérin (BCG), or radical cystectomy (RC). Current treatments are poorly tolerated, have supply limitations and often fail to control the disease.
Ruby Lister‐Whelan, Ethan Senior, Jessica Kendall, Jamie B. Oughton, Fiona Collinson, Jon Griffin, Rachel Hubbard, Steven Kennish, Aidan Noon, Derek J. Rosario, Irbaz B. Riaz, Julie Telliez, James W. F. Catto, Syed A. Hussain   +13 more
wiley   +1 more source

Successful treatment of post-intubation tracheal stenosis with balloon dilation, argon plasma coagulation, electrocautery and application of mitomycin C

Southwest Respiratory and Critical Care Chronicles, 2015
Tracheal stenosis is an uncommon but known complication of endotracheal intubation and tracheostomy. Surgery is currently the definitive treatment for tracheal stenosis but carries a significantly higher risk for adverse events as it often involves ...
Audra Fuller, Mark Sigler, Shrinivas Kambali, Raed Alalawi   +3 more
doaj