Electrochemistry of potentially bioreductive alkylating quinones : Part 1. Electrochemical properties of relatively simple quinones, as model compounds of mitomycin- and aziridinylquinone-type antitumour agents [PDF]
, 1990 The influence of methyl-, hydroxy and amino substituents on the electrochemical behaviour of simple 1,4-naphtho-and 1,4-benzoquinones, model compounds of many quinoid antitumour agents, in aqueous media was studied. Significant changes in electrochemical
Bos, M. +9 more
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Characterization of a Reductively-Activated Elimination Pathway Relevant to the Biological Chemistry of the Kinamycins and Lomaiviticins [PDF]
, 2012 The lomaiviticins (1 and 2) and kinamycins (3–5) are bacterial metabolites with potent antimicrobial and antiproliferative activities. Herein we establish that 1–5 are capable of generating electrophilic acylfulvene intermediates (6) under mildly ...
Ding, Weidong +4 more
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Synthesis of 18F-labelled 2-fluoro-1,4-quinones using acetylhypofluorite [PDF]
, 1988 The fluorination of 1,4-benzo- and naphthoquinones using [18F]acetylhypofluorite is described.
Herscheid, Jacobus D.M. +3 more
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Probing the Mechanism of DNA Protein Crosslink Formation by Aziridinomitosenes Through the Selective Precipitation of Protein Salts [PDF]
, 2023 Aziridinomitosenes are synthetic chemotherapeutic agents that are analogs of Mitomycin C, as well as other mitomycins. They are known for their ability to form DNA interstrand cross-links (ICLs), and more recently have been observed to form DNA-protein ...
Blair, Michael
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Mitomycins syntheses: a recent update
Beilstein Journal of Organic Chemistry, 2009 Mitomycins are a class of very potent antibacterial and anti-cancer compounds having a broad activity against a range of tumours. They have been used in clinics since the 1960’s, and the challenges represented by their total synthesis have challenged ...
Jean-Christophe Andrez
doaj +1 more source
Synthesis, structural characterization, antimicrobial and cytotoxic effects of aziridine, 2-aminoethylaziridine and azirine complexes of copper(II) and palladium(II). [PDF]
, 2012 The synthesis, spectroscopic and X-ray structural characterization of copper(II) and palladium(II) complexes with aziridine ligands as 2-dimethylaziridine HNCH2CMe2 (a), the bidentate N-(2-aminoethyl)aziridines C2H4NC2H4NH2 (b) or CH2CMe2NCH2CMe2NH2 (c ...
A. Hauss +81 more
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Long-term outcomes of antiproliferative agents in primary trabeculectomy [PDF]
, 2002 Purpose: To evaluate and compare long-term outcomes of trabeculectomies with subconjunctival injections of 5-fluorouracil (5-FU) after sugery or use of mitomycin C (MMC) during surgery.
Mello, Paulo Augusto de Arruda +3 more
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Photoresponsive antibiotics and cytotoxic agents:On the use of light for the advancement of medicine and the knowledge of living organisms [PDF]
, 2019 Cancer and the appearance of drug resistant bacteria are two of the major health problems of modern day society. The causes of cancer are numerous and not fully understood, making prevention difficult and treatments harsh as they cause many side effects.
Sitkowska, Kaja Dorota
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Pharmacokinetics of Mitomycin C Following Hepatic Arterial Chemoembolization With Gelfoam [PDF]
, 1992 Twelve mongrel dogs were randomly allocated into two groups using matched paired-design. Catheters were inserted into the hepatic artery, hepatic vein and the femoral vein, respectively. In the first group, gelfoam supplemented with mitomycin C (MMC) was
Andersson, R +3 more
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Photochemical aryl radical cyclizations to give (E)-3-Ylideneoxindoles [PDF]
, 2014 (E)-3-Ylideneoxindoles are prepared in methanol in reasonable to good yields, as adducts of photochemical 5-exo-trig of aryl radicals, in contrast to previously reported analogous radical cyclizations initiated by tris(trimethylsilyl)silane and azo ...
Aldabbagh, Fawaz +5 more
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