Results 71 to 80 of about 960 (156)

Synthesizing C6 and C7 Methylated Aziridinomitosenes to Elucidate Their Interactions with DNA

, 2021
Aziridinomitosenes (AZMs) are a family of cytotoxic molecules derived from the mitomycins, a family of tetracyclic molecule isolated from a soil bacterium, and used in cancer treatment, ocular surgery, and more.
Walters, Zach G., Merlo, Anthony V., Blair, Michael A., Warner, Don L.   +3 more
core  

S100A4 Orchestrates Fibroblast Fate to Drive Fibrotic Remodeling

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Fibrotic stimuli induce S100A4 expression, promoting the activation of apoptosis‐resistant fibroblasts through engagement of ERK‐associated signaling. In fibroblasts, S100A4 orchestrates fibroblast fate by enhancing migration, promoting stress fiber formation, increasing ECM contractility, upregulating α‐SMA expression, and supporting survival ...
Spring Li, Banruo Cai, Xu Zhang, Guoqiang Cai, Yong Zhou, Brant M. Wagener, Qiang Ding   +6 more
wiley   +1 more source

Studies towards enantioselective synthesis of mitomycins

, 2013
published_or_final_versionChemistryDoctoralDoctor of ...
Gu, Qiangshuai, 顧強帥
core   +1 more source

Synthesis of Oligonucleotides containing the cis-Interstrand Crosslink Produced by Mitomycins in their Reaction with DNA. [PDF]

Chemistry, 2020
Aguilar W, Zacarias O, Romaine M, Proni G, Petrovic AG, Abzalimov R, Paz MM, Champeil E.   +7 more
europepmc   +1 more source

Mitomycins

, 1967
E. J. Kirsch
core   +2 more sources

Walsh & Hoyt: Antibiotics

, 2005
The antimicrobials mostly have a chemotherapeutic effect by noncovalent DNA binding, resulting in untwisting of the double helix, intercalation, and impairment of template synthesis.
Mark L. Moster, MD; Rod Foroozan, MD
core  

Prophylactic surgery plus hyperthermic intraperitoneal chemotherapy (HIPEC CO2) versus standard surgery in colorectal carcinoma at high risk of peritoneal carcinomatosis: short-term and long-term outcomes from the CHECK study - protocol for a randomised, multicentre, phase 3 trial. [PDF]

BMJ Open, 2022
Pacelli F, Gerardi C, Rulli E, Abatini C, Rotolo S, Garattini S, Melotti G, Torri V, Galli F, Rulli E, Di Giorgio A, CHECK Investigators.   +11 more
europepmc   +1 more source

Mechanistic Studies of Aziridine Formation Catalyzed by Mononuclear Non-Heme Iron Enzymes. [PDF]

J Am Chem Soc, 2023
Cha L, Paris JC, Zanella B, Spletzer M, Yao A, Guo Y, Chang WC.   +6 more
europepmc   +1 more source

Comparative Analysis of Transcriptomic Response of <i>Escherichia coli</i> K-12 MG1655 to Nine Representative Classes of Antibiotics. [PDF]

Microbiol Spectr, 2023
Bie L, Zhang M, Wang J, Fang M, Li L, Xu H, Wang M.   +6 more
europepmc   +1 more source

Bulky Adducts in Clustered DNA Lesions: Causes of Resistance to the NER System. [PDF]

Acta Naturae, 2022
Naumenko NV, Petruseva IO, Lavrik OI.
europepmc   +1 more source