Results 81 to 90 of about 1,093 (182)
Aging Cell, Volume 25, Issue 9, September 2026.Transcriptomic analysis using a rabbit glaucoma filtration surgery model, combined with in vitro experiments on human conjunctival fibroblasts, demonstrates that mitomycin C induces a senescence‐associated secretory phenotype (SASP)‐like state. These SASP‐like fibroblasts were selectively eliminated by the specific senolytic agent, highlighting their ...
Akitoshi Kimura +12 more
wiley +1 more source
GCN2 in proteostasis: structural logic, signalling networks and disease
The FEBS Journal, Volume 293, Issue 18, Page 5627-5644, September 2026.Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley +1 more source
Journal of Gastroenterology and Hepatology, Volume 41, Issue 9, Page 2613-2622, September 2026.Esophageal distensibility and compliance provide physiologic information beyond luminal diameter alone in pediatric esophageal disease. This review proposes a practical biomechanics‐informed framework integrating FLIP assessment into interpretation of dysphagia, esophageal remodeling, dilation response, and therapeutic decision‐making in children ...
Brett J. Hoskins +2 more
wiley +1 more source
Synthesis of Oligonucleotides containing the cis-Interstrand Crosslink Produced by Mitomycins in their Reaction with DNA. [PDF]
Chemistry, 2020 Aguilar W +7 more
europepmc +1 more source
Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 554-567, September 2026.ABSTRACT Effective chemotherapy for canine histiocytic sarcoma (CHS) has yet to be established. In our previous study, CHS cell lines were subclassified into two groups based on their gene expression profiles: Group A and Group B. This study aimed to identify novel therapeutic agents that are effective against each CHS subgroup, and we performed high ...
Hiroki Sakuma +6 more
wiley +1 more source
Complications Following Nictitating Membrane Resection in Horses: 92 Eyes (2015–2024)
Veterinary Ophthalmology, Volume 29, Issue 5, September 2026.ABSTRACT Objective The goal of this retrospective study is to evaluate the complications following nictitating membrane resection in horses with the aim of providing valuable information on the risks of this surgical procedure. Animals 83 horses (92 eyes). Procedures Medical records for 83 horses that underwent nictitating membrane resection in 92 eyes
Tiantian Wu +2 more
wiley +1 more source
Veterinary Ophthalmology, Volume 29, Issue 5, September 2026.ABSTRACT Purpose To evaluate the long‐term (> 1 year) outcomes of vision and intraocular pressure (IOP) control in dogs with glaucoma undergoing combined endoscopic cyclophotocoagulation (ECP) and Ahmed valve gonioimplantation (AVG). Methods Medical records between 2020 and 2025 were reviewed. Outcomes evaluated included IOP control (< 25 mmHg), vision
Sanskruti S. Potnis +6 more
wiley +1 more source
Synthesis of Oligonucleotides Containing a Dna Distorting Interstrand Crosslink Produced by Mitomycins. [PDF]
ChembiochemMarks S +9 more
europepmc +1 more source
Prophylactic surgery plus hyperthermic intraperitoneal chemotherapy (HIPEC CO2) versus standard surgery in colorectal carcinoma at high risk of peritoneal carcinomatosis: short-term and long-term outcomes from the CHECK study - protocol for a randomised, multicentre, phase 3 trial. [PDF]
BMJ Open, 2022 Pacelli F +11 more
europepmc +1 more source