Results 161 to 170 of about 7,933 (262)

Clozapine for treatment‐resistant schizophrenia with epilepsy: A case report

open access: yesPsychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.
Clozapine (CLOZ) is often avoided in treatment‐resistant schizophrenia with comorbid epilepsy due to seizure risks. We report a successful case managed through a cautious CLOZ titration guided by multimodal monitoring, including clinical scales and blood tests such as C‐reactive protein (CRP), CLOZ levels, and anti‐seizure medication (ASM) levels ...
Toru Horinouchi   +5 more
wiley   +1 more source

“Humanizar”: aprendizajes sobre alteridad, salud y futuro en una experiencia de investigación compartida

open access: yesThe Journal of Latin American and Caribbean Anthropology, Volume 31, Issue 2, June 2026.
ABSTRACT The visit to Bogotá of a fééeneminaa (Muinane) friend, Célimo Nejedeka Jifichíu, and in particular, his work in researching and transmitting traditional health knowledge, offer the pretext to navigate the relationship between elements that at first glance seem distant from each other: indigenous imaginaries about otherness, their visions of ...
Giovanna Micarelli
wiley   +1 more source

Development of Immunoelectron Microscopy for VASN Detection Using Multiple Models and Identification of VASN as a Key Regulator of Mitochondrial Homeostasis in Hepatocellular Carcinoma Cells

open access: yesThe FASEB Journal, Volume 40, Issue 10, 31 May 2026.
We developed an optimized immunoelectron microscopy method (IEM‐VASN) for precise VASN localization, rigorously validated in both gene‐edited cells and knockout mice. Application of this method uncovered distinct mitochondrial enrichment of VASN.
Xiaojing Cheng   +11 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, Volume 16, Issue 5, Page 885-905, May 2026.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Bioinspired, Mitochondria‐Targeted Single‐Atom Nanozyme Enhances Bone Regeneration by Reprogramming Stem Cell Energy Metabolism​

open access: yesAdvanced Materials, Volume 38, Issue 26, 8 May 2026.
A bioinspired nanozyme—triphenylphosphonium (TPP)‐dendritic mesoporous silica nanoparticle (DMSN)‐Fe/Cu—mimics mitochondrial complex IV and targets mitochondria to regulate cellular energy metabolism. This approach markedly boosts bone regeneration in vivo, as demonstrated by enhanced bone volume and mineral density in critical‐sized bone defects rat ...
Yuwen Wang   +16 more
wiley   +1 more source

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