Results 171 to 180 of about 8,099 (260)

Frequency and Early Predictors of Cognitive Deterioration in Amyotrophic Lateral Sclerosis: A Longitudinal Population-Based Study. [PDF]

open access: yesAnn Neurol
Iazzolino B   +13 more
europepmc   +1 more source

Budding speciation, mitochondrial capture and introgression between surface and cave lineages in the Asellus aquaticus species complex

open access: yesCladistics, EarlyView.
Abstract Replicated pairs of ancestral and evolutionarily derived populations provide opportunities to test hypotheses about the deterministic laws of evolution. The Asellus aquaticus species complex is an invertebrate model system with several independent surface‐to‐cave transitions and a complicated and unresolved evolutionary history.
Peter Trontelj   +3 more
wiley   +1 more source

Dissection of Mitochondrial Function via Chemical Perturbation and Single‐Cell Profiling

open access: yesCell Proliferation, EarlyView.
We establish a systematic framework to dissect mitochondrial function at the module level by combining targeted chemical perturbations with scRNA‐seq. This approach reveals shared and module‐specific programs linking mitochondrial activity to mito‐nuclear communication, stress response, and cell cycle, highlighting the tight coupling between ...
Hao Luo   +4 more
wiley   +1 more source

Collagen Type VI Alpha 1 as a Regulator of Redox Homeostasis in Antioxidant‐Enhanced Osteogenesis of Dental Stem Cells

open access: yesCell Proliferation, EarlyView.
Under physiological conditions, NAC activates the PI3K‐AKT‐COL6A1 axis to sustain redox balance and enhance osteogenesis. COL6A1 deficiency, however, compromises this axis, inducing oxidative stress and impairing NAC's osteogenic efficacy. ABSTRACT Alveolar bone injury represents a prevalent clinical challenge in dentistry, for which stem cell‐based ...
Zhaosong Meng   +11 more
wiley   +1 more source

Electron tomography reveals mitochondrial network and cristae remodelling during cell differentiation in the human placenta

open access: yes
Acharya S   +15 more
europepmc   +1 more source

Oxidative Stress Drives Cell Cycle Stalling, Apoptosis and Metabolic Suppression in Cystatin B Deficient EPM1 Patient iPSCs

open access: yesCell Proliferation, EarlyView.
CSTB deficient EPM1 iPS cells manifest increased lysosomal activity and oxidative stress, which lead to DNA damage, cell cycle defects and increased apoptosis. As a protective response, metabolism is suppressed. Image created by BioRender https://BioRender.com/t44oc6h.
Shekhar Singh   +4 more
wiley   +1 more source

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