Results 31 to 40 of about 43,657 (304)

Desmembramiento genésico y fecundación mítica en las cosmovisiones de la Mesoamérica prehispánica y del Egipto faraónico

Xihmai, 2023
En la antigua Mesoamérica el principio “la muerte genera vida” permeó todas las esferas de su cosmovisión. Una de las formas de muerte es la sacrificial, en esta se contiene el desmembramiento, y los desmembramientos fueron recurrentes en las narrativas ...
Alondra Domínguez Ángeles, Gerardo P. Taber   +1 more
doaj   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Mito & contracultura

Mediações - Revista de Ciências Sociais, 2007
Considerada irracional desde os seus primórdios, a crítica à contracultura revelou-se incapaz de perceber a revolução cognitiva que se instaurava com as diferentes práticas de espiritualidade. Substituindo a lógica racionalista da exclusão pela lógica da inclusão, onde os elementos se equivalem, o movimento contracultural resgatou a experiência mítica,
openaire   +4 more sources

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

COVID-19 y escuela: ¿el espejismo de la innovación?

Educación y Ciudad, 2023
La emergencia educativa producto de la pandemia conllevó el cierre de las escuelas la mayoría de los países del mundo, durante el confinamiento estudiantes, maestros y sus familias, aunaron esfuerzos por mantener el proceso educativo.
Henry Wilson León-Calderón, Carlos Eduardo Cruz-Gómez, Dina Sofía Gualdrón-Álvarez   +2 more
doaj   +1 more source

Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer

Advanced Science, EarlyView.
Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen, Dingru Li, Yingna Liao, Zehua Wang, Chunbin Zhu, Zifeng Zhang, Liquan Jin, Yueyue Chen, Jiaoshun Chen, Junyi Xu, Miaoyan Wei, Rong Tang, Xianjun Yu, Si Shi   +13 more
wiley   +1 more source

Light‐Activatable Nitric Oxide Release via Intramolecular Electron Transfer for Tumor Pyroptosis Induction

Advanced Science, EarlyView.
This work proposes a novel strategy to fabricate unimolecular pyroptosis photoinitiators activated by deep‐red light at low light doses. It relies on a photosensitization mechanism to trigger nitric oxide (NO) release from benzisothiadiazole‐based N‐nitrosanilines without modification of nitro moieties, thereby boosting pyroptosis‐mediated ...
Chuangxin Zhang, Ruipeng Li, Yunxia Wang, Feng Liu, Liheng Feng   +4 more
wiley   +1 more source

Mitos Di Wilayah Rawa Bayu Dan Pemanfaatannya Sebagai Materi Pembelajaran Sastra Di SMA

, 2018
Rancangan dan jenis penelitian yang digunakan dalam penelitian ini adalah kualitatif etnografi. Data yang digunakan adalah hasil wawancara dengan beberapa informan mengenai mitos di wilayah Rawa Bayu.
PERMADI, Dwi Andika
core   +1 more source

Mitos y conocimiento sobre el suicidio adolescente

Revista de Psicología
El artículo presenta un estudio descriptivo de corte transversal sobre las creencias con respecto al suicidio, considerado por la OMS (2021) como una de las principales causas de muerte entre los 15 y 29 años.
Elizabeth Ormart, Valentina Stagno, Laura Díaz Cano   +2 more
doaj   +1 more source