Results 41 to 50 of about 43,657 (304)

Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells

Advanced Science, EarlyView.
In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu, Wenhao Zhang, Yifan Zhang, Yu He, Yi Du, Yiding Zhao, Chunmeng Yao, Shengyi Sun, Xiaoyan Sheng, Qian Gao, Chao Tong, Ling Shuai   +11 more
wiley   +1 more source

Mitos, ritos, identidad y alteridad en un estadio de fútbol

Revista de Dialectología y Tradiciones Populares, 2017
A partir del trabajo de investigación sobre la cultura de gradas generada en el estadio del Granada Club de Fútbol, desarrollado en el transcurso de tres temporadas futbolísticas (2013-2014, 2014-2015 y 2015-2016), centramos aquí la atención ...
Ángel Acuña Delgado, Guillermo Acuña Gómez   +1 more
doaj   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Mitos dan Kontramitos dalam Novel Mantra Penjinak Ular Karya Kuntowijoyo

Deiksis: Jurnal Pendidikan Bahasa dan Sastra Indonesia, 2018
Mitos sebagai bagian dari kehidupan merupakan salah satu inspirasi lahirnya suatu cipta sastra.  Seringkali mitos dijadikan bahan untuk menulis sastra oleh pengarang.namun demikian, asumsi korelasi antara realitas dan sastra, hadirnya mitos dalam cipta ...
Ria Kasanova, Sri Widjajanti
doaj  

Héroes, guerreros, caballeros, oligarcas: tres nuevos vasos singulares ibéricos procedentes de Libisosa

Archivo Español de Arqueología, 2013
El presente artículo se centra en la lectura iconográfica de un conjunto de vasos con decoración pintada figurada procedentes todos ellos de contextos cerrados del oppidum oretano de Libisosa, destruidos en el primer tercio del siglo I a.C.
Héctor Uroz Rodríguez
doaj   +1 more source

To’on: Mitos Masyarakat Madura dalam Menghadapi Wabah

Dialektika: Jurnal Bahasa, Sastra, dan Pendidikan Bahasa dan Sastra Indonesia, 2022
ABSTRAK Sejarah mengenai wabah yang dialami oleh masyarakat Madura ditandai dengan adanya kepercayaan mereka terhadap mitos To’on. Dari sekian banyaknya wabah yang merebak dalam sejarah peradaban masyarakat Madura, mereka hanya mengidentifikasi wabah ...
Atiqotul Fitriyah, Nella Putri Giriani, Muhammad Fadhly Kurniawan   +2 more
doaj   +1 more source

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

Lenguaje metafórico en el mundo del fútbol

Apunts: Educación Física y Deportes, 2017
El propósito de este estudio es demostrar que el fútbol actual se ha convertido en un sustituto de la religión. No solo como un hecho trascendente sino como un hecho real. La dimensión planetaria que este ha adquirido en los últimos años, nos puede hacer
Javier Arranz Albó
doaj   +1 more source

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li, Yajin Liao, Yan‐bo Zhao, Hongxing Wu, Tong Jin, Shuoshuo Li, Yuhan Liu, Peng Li, Songying Ouyang, Zekai Li, YuTing Xia, Qian Hua, Rui‐Yuan Pan, Zengqiang Yuan   +13 more
wiley   +1 more source