Results 51 to 60 of about 59,394 (245)

Representación social de la pobreza

INFAD
Actualmente, no pocas veces continúan vigentes patrones de comportamiento discriminatorio contra las personas que se encuentran en situación de pobreza, apoyados en mitos, falsas creencias, ideas estereotipadas, prejuicios y estigmas hacia las personas ...
Beatriz Lázara Gandarillas, Ana Isabel Isidro de Pedro   +1 more
doaj   +1 more source

Verdadeiro ou falso? Uma análise dos mitos que permeiam a temática das altas habilidades/ superdotação

Revista Educação e Emancipação, 2017
Além do desconhecimento sobre as especificidades que compõem o fenômeno da superdotação, os mitos constituem-se  em mais um fator que dificulta o processo de identificação e avaliação de estudantes com Altas Habilidades/Superdotação (AH/SD) e o ...
Ketilin Mayra Pedro, Clarissa Maria Marques Ogeda, Miguel Cláudio Moriel Chacon   +2 more
doaj   +1 more source

PDGFRα+/Integrin α2+ Fibroblasts Orchestrate Tumor Budding in Oral Squamous Cell Carcinoma via Mechano‐Metabolic Symbiosis: E‐Cadherin/Integrin α2β1 Adhesion and Mitochondrial Transfer

Advanced Science, EarlyView.
PDGFA/PDGFRα signaling recruits CAFs to OSCC nests, and CAF‐OSCC contact drives tumor budding invasion. Mechanistically, heterotypic adhesion via E‐cadherin/integrin α2β1 activates YAP signaling in OSCC cells, inducing EMT. Concurrently, CAFs transfer mitochondria through TNTs, supplying ATP to fuel invasion.
Yufang Liu, Jiao Li, Juan Liu, Qi Dong, Haoyang Zhang, Yanjin Wang, Huibing Li, Ye Guan, Lei Cao, Manqing Zhang, Fangning Guo, Xue Liu, Zhen Yang, Mengmeng Lu, Hui Liu, Laiping Zhong, Tong Ji, Tingjiao Liu   +17 more
wiley   +1 more source

Biomimetic Nanoplatform for Dual Target Nano‐Metabolic Therapy in Diabetes‐Associated Biofilm Infections

Advanced Science, EarlyView.
A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li, Yonglong Li, Jiren Yan, Changming Wang, Jinlong Yu, Feng Jiang, Boyong Wang, Yi Yang, Deyi Ding, Jin Tang, Pei Han, Botao Song, Geyong Guo, Hao Shen   +13 more
wiley   +1 more source

LRRC4 Orchestrates AP2A1‐Containing Clathrin‐Coated Vesicles to Disrupt Mitochondrial Cristae and Restrict Glioblastoma Progression

Advanced Science, EarlyView.
LRRC4 suppresses GBM by regulating AP2A1‐containing Golgi‐derived clathrin‐coated vesicles. Low LRRC4 allows cytoplasmic AP2A1 to maintain mitochondrial fission‐fusion, MICOS integrity, and OXPHOS, promoting proliferation and invasion. High LRRC4 redirects AP2A1‐containing Golgi‐derived clathrin‐coated vesicles to mitochondria, disrupts MICOS, enhances
Yang Li, Cheng Huang, Liangqi Jiang, Zhen Li, Qing Liu, Minghua Wu   +5 more
wiley   +1 more source

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

Los mitos raciales [PDF]

, 1956
Juan Comas expone algunos mitos sobre los que se basa la teoría racista y analiza varios ejemplos de prejuicios raciales, basados en una falsa superioridad, que se han dado a lo largo de la ...
Comas, Juan
core   +1 more source

Actualidad cosmopolita del concepto de “proximidad” de Yolanda Oreamuno

Revista Espiga, 2005
A los setenta años, casi, de “El ambiente tico y los mitos tropicales”, de Yolanda Oreamuno, conviene releer este ensayo y comprobar su sorprendente frescura. No solo son vigentes sus observaciones respecto de la democracia, como se vive aquí, en sentido
Víctor Valembois
doaj   +1 more source

TPI1 Loss Triggers a Metabolite‐Driven Mitochondrial Redox Vulnerability via the SARM1–cADPR–Ca2+ Axis

Advanced Science, EarlyView.
Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu, Shun Wu, Chuang Wang, Zirui Zhou, Tianwei Cai, Wen Tao, Shidong Zuo, Chi Zhang, Yuhao Dong, Yi Feng, Qingbo Huang, Baojun Wang, Xin Ma, Haoli Ma, Xu Zhang, Yan Huang   +15 more
wiley   +1 more source

LUBANG BUAYA: MITOS DAN KONTRA-MITOS [PDF]

, 2020
Wacana tentang Lubang Buaya merupakan salah satu wacana dominan dalam masa pemerintahan Orde Baru. Narasi-narasi resmi yang diproduksi negara (state) dan direproduksi masyarakat (society) cenderung menyebarkan kesan menakutkan bahkan menyeramkan. Tulisan
Taum, Yoseph Yapi
core   +1 more source