Results 91 to 100 of about 379,827 (391)

Checkpoints are blind to replication restart and recombination intermediates that result in gross chromosomal rearrangements [PDF]

, 2015
Replication fork inactivation can be overcome by homologous recombination, but this can cause gross chromosomal rearrangements that subsequently missegregate at mitosis, driving further chromosome instability.
A Janssen, A Letessier, AT Watson, AT Watson, BJ Brewer, C Lukas, D Branzei, E Ampatzidou, E Tsang, EK Schwartz, HD Lindsay, I Miyabe, J Bartkova, J Matos, JA Harrigan, JM Murray, K Mizuno, K Mizuno, K Tanaka, KL Chan, KL Chan, LJ Gaskell, MN Boddy, NC Walworth, O Limbo, P Huertas, PM Dehe, RA Burrell, S Lambert, S Lambert, S Minocherhomji, S Sarbajna, S Ying, SC Ip, SG Durkin, SM Mirkin, T Caspari, V Naim, VG Gorgoulis, X Li   +39 more
core   +1 more source

Engineering Cellular Self‐Adhesions Inside 3D Printed Micro‐Arches to Enhance Cell:Biomaterial Attachment

Advanced Materials, EarlyView.
Surprisingly, a cell can bind to itself to make a self‐adhesion, which engineered here to improve how cells attach to biomaterials. Nanoprinting are used to make 3D structures smaller than cells–called Self‐Adhesion‐Tunnels (SATs)–around which cells can wrap and bind to themselves.
Anamika Singh, Hannah E. Kim, Lauren Rawson, Margaret Miao, Daniel J. Cohen   +4 more
wiley   +1 more source

Fission yeast neddylation ligase Dcn1 facilitates cohesin cleavage and chromosome segregation at anaphase

Biology Open, 2017
Post-translational protein modification such as phosphorylation and ubiquitination are critical during mitosis to ensure proper timing and progression of chromosome segregation.
Lan Lin, Li Chen, Phong T. Tran
doaj   +1 more source

Cyclin F Is Degraded during G2-M by Mechanisms Fundamentally Different from Other Cyclins [PDF]

, 2002
Cyclin F, a cyclin that can form SCF complexes and bind to cyclin B, oscillates in the cell cycle with a pattern similar to cyclin A and cyclin B. Ectopic expression of cyclin F arrests the cell cycle in G2/M.
Fung, Tsz Kan, Lau, Anita, Poon, Randy Y. C., Siu, Wai Yi, Yam, Cain H.   +4 more
core   +1 more source

Biocompatible Porphyrin Derivatives Electron Beam and Extreme Ultraviolet Photoresists: High Resolution and High Etch Resistance

Advanced Materials Interfaces, EarlyView.
Porphyrin derivatives are introduced for electron beams and extreme ultraviolet lithography. The lithographic performance of the novel CuTP‐4Epoxy photoresist is excellent, with a resolution of 18 nm in EBL and 20 nm in EUVL, and the photoresist also exhibits high etch resistance.
Yurui Wu, Siliang Zhang, Xuewen Cui, Xue Cong, Shuang Liu, Lei Wang, Xudong Guo, Rui Hu, Shuangqing Wang, Jinping Chen, Yi Li, Jun Zhao, Shumin Yang, Yanqing Wu, Guoqiang Yang   +14 more
wiley   +1 more source

Advances in Microfluidic Cochlea‐On‐A‐Chip

Advanced Science, EarlyView.
This review systematically examines diverse cell sources for inner ear organoids and outlines stepwise induction protocols. Furthermore, it discusses current applications and prospective developments of cochlea‐on‐a‐chip technologies in areas such as deafness modeling, mechanistic studies, and drug evaluation, with particular focus on gene‐therapy drug
Tian Shen, Shanying Han, Weiwei He, Wen Yang, Xinghua Tang, Xiaolong Zhao, Xinghong Liu, Zhenhua Shao, Lin Cheng, Yu Zhao, Jiangang Fan   +10 more
wiley   +1 more source

A hyperactive transcriptional state marks genome reactivation at the mitosis–G1 transition

bioRxiv, 2016
During mitosis, RNA polymerase II (Pol II) and many transcription factors dissociate from chromatin, and transcription ceases globally. Transcription is known to restart in bulk by telophase, but whether de novo transcription at the mitosis-G1 transition
C. Hsiung, C. Bartman, Peng Huang, Paul Ginart, A. Stonestrom, C. Keller, Carolyne J. Face, Kristen S. Jahn, Perry Evans, Laavanya Sankaranarayanan, B. Giardine, R. Hardison, A. Raj, G. Blobel   +13 more
semanticscholar   +1 more source

Topoisomerase I Inhibition in ETV4‐overexpressed Non‐Small Cell Lung Cancer Promotes Replication and Transcription Mediated R‐Loop Accumulation and DNA Damage

Advanced Science, EarlyView.
The oncogenic ETS factor ETV4 exerts a pleiotropic control over DNA replication both in a transcription‐dependent and ‐independent fashion in NSCLC cells. High‐ETV4 expression leads to R‐loop formation and DNA damage in response to TOP1 inhibition.
Jiaxi Zhang, Yan Wang, Shanhu Cao, Shelly M. Xie, Bei Liu, Yimeng Li, Yuqi Hou, Xue Meng, Mingzhu Ruan, Di Bu, Jia Kang, Ruxin Li, Lei Lou, Juan Wang, Lingxiao Xing   +14 more
wiley   +1 more source

Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules [PDF]

, 2017
Tubulin-targeting molecules are widely used cancer therapeutic agents. They inhibit microtubule-based structures, including the mitotic spindle, ultimately preventing cell division.
Coluccia, Antonio, Cundari, Enrico, DI CESARE, Erica, Famiglini, Valeria, Giubettini, Maria, LA REGINA, Giuseppe, Lavia, Patrizia, Miele, Andrea, Rovella, Paola, Silvestri, Romano, Verrico, Annalisa   +10 more
core   +1 more source

Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy

Advanced Science, EarlyView.
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao, Tian Shen, Shengda Cao, Ziyi Liu, Wendu Pang, Meixuan Li, Jingjing Liu, Wen Li, Yunhao Wu, Chengcheng Liu, Ming Xia, Xiaolong Fu, Cheng Cheng   +12 more
wiley   +1 more source