Results 91 to 100 of about 329,783 (340)

CCDC41 Drives Oocyte Meiotic Progression by Promoting Rab11a/Rab7‐Positive Vesicle Fusion with Target Membranes

Advanced Science, EarlyView.
CCDC41 is essential for meiotic maturation in mouse oocytes through regulating Rab7‐positive endosomes fusion with lysosomes and Rab11a‐positive vesicle fusion with the plasma membrane. Abstract Coiled‐coil domain‐containing protein 41 (CCDC41), a core component of centriolar distal appendages involved in centriole assembly and ciliary vesicle docking,
Ying Tian, Jiatong Li, Jingyi Kang, Xiangning Xu, Bicheng Wang, Shuo Lou, Jingyu Li, Yuying Yang, Yanbing Zhang, Yangzi Zheng, Jing Weng, Yuanjing Liang, Wei Ma   +12 more
wiley   +1 more source

Deficiency of mastl, a mitotic regulator, results in cell detachment from developing tissues of zebrafish embryos

Frontiers in Cell and Developmental Biology
To form tissues with unique functions and structures, it is important that the cells that comprise them maintain physical contact. On the other hand, with each mitosis, drastic changes in cell shapes, cell adhesion, and cytoskeletal architecture may ...
Hideko Utsumi, Hideko Utsumi, Taijiro Yabe, Taijiro Yabe, Taijiro Yabe, Sumito Koshida, Sumito Koshida, Sumito Koshida, Akira Yamashita, Akira Yamashita, Akira Yamashita, Shinji Takada, Shinji Takada, Shinji Takada   +13 more
doaj   +1 more source

Faculty Opinions recommendation of Phosphorylation and chromatin tethering prevent cGAS activation during mitosis.

, 2021
Jean‐Luc Imler
openalex   +2 more sources

Assessment of algorithms for mitosis detection in breast cancer histopathology images [PDF]

, 2014
The proliferative activity of breast tumors, which is routinely estimated by counting of mitotic figures in hematoxylin and eosin stained histology sections, is considered to be one of the most important prognostic markers.
Adnan M. Khan, Al-Janabi, Al-Janabi, Alessandro Giusti, Anant Madabhushi, Anders B. Dahl, Anders B.L. Larsen, Angel Cruz-Roa, Beliën, Bogdan J. Matuszewski, Ching-Wei Wang, Ciresan, Ciresan, Ciresan, Dan C. Cireşan, Elston, Evdokia Arkoumani, F. Boray Tek, Fabio Gonzalez, Frederic Precioso, Gurcan, Haibo Wang, Harder, Huisman, Irshad, Jacob S. Vestergaard, Josef Kittler, Josien P.W. Pluim, Jürgen Schmidhuber, Kaman, Khan, Larsen, Luca M. Gambardella, Malon, Max A. Viergever, Miangela M. Lacle, Mitko Veta, Nasir M. Rajpoot, Padfield, Paul J. van Diest, Roux, Ruifrok, Satoshi Kondo, Seiffert, Stathonikos, Stefan M. Willems, Tek, ten Kate, Teofilo E. de Campos, Thomas Walter, Titsias, van Diest, van Diest, Veta, Violet Snell, Walter, Walter, Wang, Wang, Wang   +59 more
core   +5 more sources

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Unveiling an Arpp-19 phosphorylation switch that grants chromosome stability

Communications Biology
During cell division, the onset of mitosis is granted by activation of cyclin B-dependent kinase 1 (Cdk1), master mitotic kinase, coordinated with inactivation of Cdk1-counteracting phosphatases.
Angela Flavia Serpico, Caterina Pisauro, Asia Trano, Domenico Grieco   +3 more
doaj   +1 more source

Ki-67 and CDK1 control the dynamic association of nuclear lipids with mitotic chromosomes

Journal of Lipid Research
Nuclear lipids play roles in regulatory processes, such as signaling, transcriptional regulation, and DNA repair. In this report, we demonstrate that nuclear lipids may contribute to Ki-67-regulated chromosome integrity during mitosis.
Hsiao-Tang Hu, Ueh-Ting Tim Wang, Bi-Chang Chen, Yi-Ping Hsueh, Ting-Fang Wang   +4 more
doaj   +1 more source

A simple biophysical model emulates budding yeast chromosome condensation

eLife, 2015
Mitotic chromosomes were one of the first cell biological structures to be described, yet their molecular architecture remains poorly understood. We have devised a simple biophysical model of a 300 kb-long nucleosome chain, the size of a budding yeast ...
Tammy MK Cheng, Sebastian Heeger, Raphaël AG Chaleil, Nik Matthews, Aengus Stewart, Jon Wright, Carmay Lim, Paul A Bates, Frank Uhlmann   +8 more
doaj   +1 more source

Epstein‐Barr Virus Expressed Long Non‐Coding RNA (lncBARTs) Regulate EBV Latent Genome Replication

Advanced Science, EarlyView.
EBV produces abundant level of lncBARTs, which are essential for maintaining viral genome replication in EBV‐associated cancers. LncBARTs interact with a complex comprising BRD4, CTCF and viral protein EBNA1 at EBV oriP region. This interaction tethers oriP to host chromosomes, facilitating EBV episome replication.
Jiayan Liu, Dittman Lai‐Shun Chung, Larry Ka‐Yue Chow, Shuo Han, Wenkai Yi, Conor J. Cremin, Yingyin Liao, Pui Wang, Bobo Wing‐Yee Mok, Mingfang Ji, Jian Yan, Wei Dai, Honglin Chen   +12 more
wiley   +1 more source

Developing cell biology

eLife, 2013
Experiments in Xenopus embryo extracts reveal that changes in cellular biochemistry cause mitotic spindles to decrease in size over the course of early development.
Daniel Needleman
doaj   +1 more source