Results 91 to 100 of about 386,071 (373)

Cisternal Organization of the Endoplasmic Reticulum during Mitosis [PDF]

, 2009
The endoplasmic reticulum (ER) of animal cells is a single, dynamic, and continuous membrane network of interconnected cisternae and tubules spread out throughout the cytosol in direct contact with the nuclear envelope.
Adam Linstedt, Anderson D. J., Baumann O., Beaudouin J., Bobinnec Y., Boucrot E., Du Y., Ellenberg J., Ferko M. C., Fricker M., Hu J., Jesch S. A., Kremer J. R., Lei Lu, Mark S. Ladinsky, Mastronarde D. N., Mastronarde D. N., McCullough S., Ostlund C, Puhka M., Saffarian S., Shibata Y., Shibata Y., Terasaki M., Tom Kirchhausen, Voeltz G. K., Voeltz G. K., Waterman-Storer C. M., Yang L., Zhai Y.   +29 more
core   +3 more sources

Femtosecond‐Laser‐Fabricated 3D CYTOP Microfluidic Chips Enabling Super‐Resolution Live Imaging of Cell Behavior in Confined Microspaces

Advanced Materials Technologies, EarlyView.
Using two‐photon polymerization of SU‐8 together with mold processing allowed the creation of defect‐free, flexible 3D microfluidic structures with sub‐micrometer precision in CYTOP. The fabricated CYTOP microfluidic chips enabled super‐resolution imaging of cancer cells in the microchannels, clearly visualizing previously undetectable fine structural ...
Koji Sugioka, Mirai Hanzawa, Kotaro Obata, Sota Matsumoto, Masatoshi Takagi, Asako Sakaue‐Sawano, Asako Tosaki, Satoshi Shimozono, Felix Sima, Hiroyuki Kawano, Takuro Tojima, Daisuke Miyashiro, Kazunari Ozasa, Yasutaka Hanada, Godai Miyaji, Akihiko Nakano, Atsushi Miyawaki   +16 more
wiley   +1 more source

Augmented Mitotic Cell Count using Field Of Interest Proposal

, 2018
Histopathological prognostication of neoplasia including most tumor grading systems are based upon a number of criteria. Probably the most important is the number of mitotic figures which are most commonly determined as the mitotic count (MC), i.e ...
Aubreville, Marc, Bertram, Christof A., Klopfleisch, Robert, Maier, Andreas   +3 more
core   +1 more source

A hyperactive transcriptional state marks genome reactivation at the mitosis–G1 transition

bioRxiv, 2016
During mitosis, RNA polymerase II (Pol II) and many transcription factors dissociate from chromatin, and transcription ceases globally. Transcription is known to restart in bulk by telophase, but whether de novo transcription at the mitosis-G1 transition
C. Hsiung, C. Bartman, Peng Huang, Paul Ginart, A. Stonestrom, C. Keller, Carolyne J. Face, Kristen S. Jahn, Perry Evans, Laavanya Sankaranarayanan, B. Giardine, R. Hardison, A. Raj, G. Blobel   +13 more
semanticscholar   +1 more source

Phase‐Separation of YAP Mediates AJUBA Super Enhancer Activation to Promote Aberrant Mitosis in Breast Cancer

Advanced Science, EarlyView.
YAP undergoes phase separation to activate the AJUBA super‐enhancer, driving aberrant mitosis through spindle checkpoint dysregulation in breast cancer. This study uncovers a mechanistic link between YAP condensates, super‐enhancer activation, and aneuploidy formation.
Rui Zhang, Qingwen Huang, Zhuo Chen, Weijian Meng, Hongliang Dong, Zhihong Qi, Liang Liu, Jie Shen, Daxing Xie   +8 more
wiley   +1 more source

Proliferative index using Ki-67 index in reactive mesothelial versus metastatic adenocarcinoma cells in serous fluid

Advanced Biomedical Research, 2012
Background: The cytological diagnoses of serous effusions are usually made by routine cytomorphology with certainty. However, overlapping cases sometimes exist between reactive mesothelial and adenocarcinoma cells.
Noushin Afshar Moghaddam, Alireza Rahmani, Diana Taheri, Mojtaba Mokhber Desfuli   +3 more
doaj   +1 more source

Mechanobiological Dynamics‐Inspired Mechanomodulatory Biomaterials

Advanced Science, EarlyView.
Recent advances in biomaterial‐mediated mechanomodulation of stem cell fate, encompassing 2, 3, and 4D systems and their synergy with artificial intelligence is overviewed. By integrating knowledge from diverse fields, this review ultimately aims to inspire the design of smarter biomaterial systems that can accelerate the clinical translation of ...
Letao Yang, Pengfei Jiang, Joshua B Stein, Yannan Hou, Chaochen Zhou, Heemin Kang, Ki‐Bum Lee   +6 more
wiley   +1 more source

Giant cell formation produced by laser microbeam irradiation of chromatin in Chinese hamster cells [PDF]

, 1981
A pulsed laser microbeam of wavelength 532 nm was used to produce visible small lesions in the nucleoplasm or in the cytoplasm of V79 Chinese hamster cells.
Altmann, Berns, Berns, Berns, Berns, Berns, Berns, Berns, Berns, Berns, Burkhardt, Cain, Cremer, Cremer, Cremer, Cremer, Dreher, Factor, Geisinger, Hetzel, Kitzes, Leder, Leuchtenberger, Meredith, Moreno, Nakanishi, Peterson, Rattner, Schneider, Scott, Stevenson, Strahs, Tam, Tchakhotine, Wang   +34 more
core   +2 more sources

ROS Activated NETosis of Bone Marrow CD55+ Intermediate Mature Neutrophils Through HIF1α‐PADI4 Pathway to Initiate Bone Aging

Advanced Science, EarlyView.
In this study, we find CD55+ neutrophils show activated NETosis within bone marrow, induce BMSC senescence and osteogenesis inhibition, finally leading to bone aging initiation. Mechanistically, ROS synergizes with the CD55‐driven HIF1α‐PADI4 pathway to promote NETosis.
Yutong Guo, Shengjie Cui, Xi Wen, Yidi Wang, Ben Wu, Yixiang Wang, Yan Gu   +6 more
wiley   +1 more source

Non-autonomous insulin signaling delays mitotic progression in C. elegans germline stem and progenitor cells.

PLoS Genetics
Stem and progenitor cell mitosis is essential for tissue development and homeostasis. How these cells ensure proper chromosome segregation, and thereby maintain mitotic fidelity, in the complex physiological environment of a living animal is poorly ...
Eric Cheng, Ran Lu, Abigail R Gerhold
doaj   +1 more source