Results 151 to 160 of about 380,556 (390)
When the Clock Is Ticking: The Role of Mitotic Duration in Cell Fate Determination
BioEssays, EarlyView.Recently, several studies identified mechanisms by which cells measure mitotic duration and how this influences cell fate, leading to normal cell cycle progression or G1 arrest. In light of drug‐resistant cancer cells that continue proliferating even after mitotic errors, understanding these mechanisms opens the door for new potential therapeutic ...
Cornelia Sala, Elmar Schiebel
wiley +1 more source
Nature Communications, 2015 TANK Binding Kinase 1 (TBK1) is a non-canonical IκB kinase that contributes to KRAS-driven lung cancer. Here we report that TBK1 plays essential roles in mammalian cell division.
S. Pillai +5 more
semanticscholar +1 more source
Conformational Rearrangement of Fission DSPs
BioEssays, EarlyView.Assembly properties of fission DSPs. Fission DSPs exist in a dynamic equilibrium of oligomer states in the cytosol, where they must be activated by partner proteins or lipid to induce assembly, and upon GTP hydrolysis, constriction. ABSTRACT Dynamin superfamily proteins (DSPs) are large GTPases that play crucial roles in membrane remodeling processes ...
Anelise N. Hutson +2 more
wiley +1 more source
Orientation of the Mitochondria during Mitosis [PDF]
, 1949 Erik G. Christiansen
openalex +1 more source
Eukaryogenesis From FECA to LECA: Radical Steps Along the Way
BioEssays, EarlyView.How did the last eukaryotic common ancestor (LECA) population evolve? Recent evidence shows an Asgard archaeon‐like organism acquiring a bacterium, the future mitochondrion, going from symbiosis to endosymbiosis. I postulate that almost all salient LECA characteristics could have resulted from the ensuing enhanced ATP generation and internal reactive ...
Dave Speijer
wiley +1 more source
Action of Beryllium on Cells cultivated in vitro; Effect on Mitosis [PDF]
, 1951 M Chèvremont, H Firket
openalex +1 more source
Journal of Cell Science, 1989 ABSTRACT Drosophila is an attractive organism in which to study both the rapid rounds of mitosis typical of embryonic development in many species, and the longer cell cycles of diploid tissues later in development. Mutations in genes essential for mitosis in Drosophila may result in lethality in late embryonic, larval or pupal stages of ...
openaire +4 more sources
Revisiting Clonal Evolution Through the Light of Retrotransposons
BioEssays, EarlyView.We propose integrating retrotransposons into the clonal evolution model of cancer. Retrotransposons can modulate cancer cell fitness, potentially influencing clonal dynamics. They might also induce lineage violations via cell fusion or horizontal transfer.
Anaïs Lamoureux +3 more
wiley +1 more source
Breaking barriers: the cGAS‐STING pathway as a novel frontier in cancer immunotherapy
Cancer Communications, EarlyView.Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan +5 more
wiley +1 more source