Results 191 to 200 of about 379,827 (391)

An Orthogonal Way of Writing the Tubulin Code

open access: yesCytoskeleton, EarlyView.
ABSTRACT The Elongator complex has long been characterized for its role in tRNA modification and modulation of protein translation. Beyond these established functions, recent findings reveal an unexpected role for Elongator in directly interacting and tuning microtubule dynamics and properties, broadening its biological significance in eukaryotic cells.
Vicente Jose Planelles‐Herrero   +1 more
wiley   +1 more source

In Vitro Live Cell Imaging Reveals Nuclear Dynamics and Role of the Cytoskeleton During Asymmetric Division of Pollen Mitosis I in Nicotiana Benthamiana

open access: yesCytoskeleton, EarlyView.
ABSTRACT Pollen is a male gametophyte of angiosperms. Following meiosis, the microspore undergoes an asymmetric division called pollen mitosis I (PMI), which produces two cells of different sizes: a large vegetative cell and a small generative cell. Polarized nuclear migration and positioning during PMI are important for successful pollen development ...
Yoko Mizuta   +5 more
wiley   +1 more source

Inhibition of the Clathrin Terminal Domain—Amphiphysin Protein–Protein Interaction. Probing the Pitstop 2 Aromatic Moiety

open access: yesChemMedChem, EarlyView.
Pitstop 2 binds to the clathrin terminal domain. This work explores the nature of the benzylidene moiety, R. The synthesis of 56 novel analogues reveals enhanced potency of a multiple analogues, with catechol‐free 2,3‐dihydroxybenzo[b][1,4]dioxone (54) returning a 1.2 μm IC50, ca 10‐fold more active than Pitstop 2. Pitstop 2, (Z)‐N‐(5‐(4‐bromenzylidene)
Kate Prichard   +10 more
wiley   +1 more source

Hallmarks of Neuroblastoma—Pathophysiology, Diagnosis, and Therapeutic Interventions

open access: yesCancer Nexus, EarlyView.
ABSTRACT Neuroblastoma, the most common extracranial solid tumor in childhood, continues to challenge clinicians and researchers because of its heterogeneous nature and complex pathophysiology. Recent breakthroughs in molecular profiling revealed intricate genetic alterations driving tumor progression, necessitating an updated perspective on the ...
Abhimanyu Thakur, Anne Dijkstra
wiley   +1 more source

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