Results 121 to 130 of about 57,200 (262)

Degenerative mitral valve regurgitation: best practice revolution

, 2020
Degenerative mitral valve disease often leads to leaflet prolapse due to chordal elongation or rupture, and resulting in mitral valve regurgitation. Guideline referral for surgical intervention centres primarily on symptoms and ventricular dysfunction ...
Volkmar Falk, David H Adams, Raphael Rosenhek   +2 more
core  

The Novel ACTC1 p.Gly50Ser Variant Is Associated With Arrhythmia and Secondary Features of HCM Without Hypertrophy

American Journal of Medical Genetics Part A, Volume 200, Issue 7, Page 1742-1748, July 2026.
ABSTRACT The key diagnostic criterion for hypertrophic cardiomyopathy is the presence of otherwise unexplained hypertrophy. Current definitions of HCM rely on specific thresholds to establish a diagnosis, while guideline directed risk stratification algorithms take its magnitude into consideration.
Thomas D. Gossios, Dimitrios Ntelios, Thomas Zegkos, Despoina Parcharidou, Pavlos Rouskas, Sotirios Katranas, Ioannis Papoulidis, Vlasis Ninios, Antonios Ziakas, Georgios K. Efthimiadis   +9 more
wiley   +1 more source

Percutaneous mitral valve commissurotomy

, 2019
Transcatheter therapies have progressively assumed a major role in the treatment of valve heart disease. The major drivers have been population ageing, the high prevalence of valve disease in the elderly, and the consequent need of less invasive ...
Mauro Massussi, Giuseppe Tarantini, Antonio G. Bruno, Francesco Saia   +3 more
core  

Differentiating the Clinical and Variant Spectrum of Hardikar Syndrome From Other MED12 ‐Related Developmental Disorders

American Journal of Medical Genetics Part A, Volume 200, Issue 7, Page 1619-1650, July 2026.
ABSTRACT The rare X‐linked female‐restricted Hardikar syndrome (HDKR, OMIM # 301068) is characterized by multiple congenital anomalies including orofacial clefts, gastrointestinal, genitourinary, and cardiac anomalies, but cognitive and neurobehavioral development is rarely impaired.
Tinne Warmoeskerken, Miel Theunis, Kris Van den Bogaert, Koenraad Devriendt, Jeroen Breckpot   +4 more
wiley   +1 more source

Pre‐Sport Cardiac Evaluation in Children: Detection of Risks Other Than Sudden Cardiac Death

Annals of Noninvasive Electrocardiology, Volume 31, Issue 4, July 2026.
In children who want to play sports, is a cardiac evaluation necessary only for sudden cardiac death? ABSTRACT Objective Sudden deaths may occur in children and adolescents due to unexpected cardiac problems during sports. This study aimed to screen for abnormalities that may lead to future morbidity in addition to the risk of sudden death and to ...
Mehmet Öncül, Abdulgani Gülyüz
wiley   +1 more source

Clinical and echocardiographic results of the MEMO 4D semi-rigid annuloplasty ring

Journal of Cardiothoracic Surgery
Background Mitral regurgitation is a frequent valvular disease, with an increasing prevalence. We analyzed the short-term outcomes of mitral valve repair procedures conducted in our clinic using a new semirigid annuloplasty ring featuring a gradual ...
Corrado Fiore, Marcello Melone, Kia Vaziri Farahani, Rebani Sinani, Anna Nicoletti, Luigi Specchia, Giuseppe Santarpino, Giuseppe Speziale   +7 more
doaj   +1 more source

The Diagnostic Odyssey of a Biochemically Confirmed Case of ML II: The First Western Patient With LYSET Deficiency

Clinical Genetics, Volume 110, Issue 1, Page 125-130, July 2026.
We identify a female patient with a homozygous nonsense variant (p.Gln38Ter) in the LYSET gene. This is the first western report of a challenging case of an extensive diagnostic odyssey and demonstrates that the LYSET gene must be considered in the differential diagnosis when M6P‐labeled lysosomal enzymes are altered.
Fernanda Sperb‐Ludwig, Taciane Alegra, Leonardo Martinello da Rosa, Nataniel Floriano Ludwig, Renata Voltolini Velho, Ida Vanessa Doederlein Schwartz   +5 more
wiley   +1 more source

Functional Mitral Regurgitation Post-Isolated Aortic Valve Replacement

Background: The management of mitral regurgitation during aortic valve replacement remains a complex question. Secondary mitral regurgitation often improves post-aortic valve replacement without mitral valve surgery, but residual mitral regurgitation can
Slobodan Pesic, Sasa Borovic, Dusan Andric, Jovan Petrovic, Milorad Sevkovic, Mihailo Neskovic, Petar Dabic, Bojan Vucurevic   +7 more
core   +1 more source

Compassionate use of the PASCAL transcatheter mitral valve repair system for patients with severe mitral regurgitation: a multicentre, prospective, observational, first-in-man study.

, 2017
BACKGROUND Severe mitral regurgitation is associated with impaired prognosis if left untreated. Using the devices currently available, transcatheter mitral valve repair (TMVr) remains challenging in complex anatomical situations.
Spargias, Konstantinos, Konstantinos Spargias, Florian Deuschl, Fam, Neil P, Webb, John, Edwards, Jeremy, Saibal Kar, Fabien Praz, Robert Schueler, John Webb, Kar, Saibal, Moody Makar, Michael Chrissoheris, Neil P Fam, Boone, Robert, Lutz Büllesfeld, Nickenig, Georg, Windecker, Stephan, Robert Moss, Praz, Fabien, Ted Feldman, Jeremy Edwards, Chrissoheris, Michael, Deuschl, Florian, Robert Boone, Büllesfeld, Lutz, Feldman, Ted, Aris Moschovitis, Schäfer, Ulrich, Stephan Windecker, Moschovitis, Aris, Makar, Moody, Moss, Robert, Georg Nickenig, Ulrich Schäfer, Schueler, Robert   +35 more
core   +1 more source

3D‐Printed Dynamic Heart Model With Left‐Side Anatomy and Integrated Sensor for Edge‐to‐Edge Repair and Regurgitation Reduction

Advanced Materials Technologies, Volume 11, Issue 11, 5 June 2026.
This work presents a fully synthetic, 3D‐printed dynamic heart model with left‐side anatomy featuring sutured mitral valve chordae tendineae analogs, embedded actuators for physiologic wall contraction, and customized flexible pressure sensors for the left ventricle.
Alejandro Guillen Obando, Hongyi Shen, Myles McGovern, Yusen Zhang, Vivien Lin, Darryl Fu, Ryan Baumwart, Kaiyan Qiu   +7 more
wiley   +1 more source