Results 111 to 120 of about 219,022 (300)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Ground state solutions of nonlocal equations with variable exponents and mixed criticality

Boundary Value Problems
In this article, we use approximation techniques and variational methods to study a class of nonlocal equations with variable exponents and mixed criticality. We prove the existence of the ground state nontrivial solutions with the least energy.
Yuhang Long, Xingwen Chen, Qiongfen Zhang   +2 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

On the Safety of Mixed-Criticality Scheduling

, 2016
International audienceA common assumption for scheduling mixed-criticality systems is the degradation of less critical tasks when the system is in the emergency mode; which is entered when critical tasks overrun their expected WCET.
Huang, Pengcheng, Thiele, Lothar, Draskovic, Stefan   +2 more
core   +1 more source

Transmission scheduling for mixed-critical multi-user multiple-input and multiple-output industrial cyber-physical systems

International Journal of Distributed Sensor Networks, 2017
Wireless sensor networks are widely used in industrial cyber-physical system installations, where high reliability and the need for real-time data are the two main characteristics. A large amount of real-time data can be transmitted to its destination on
Changqing Xia, Xi Jin, Linghe Kong, Jintao Wang, Peng Zeng   +4 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Towards Compositional Mixed-Criticality Real-Time Scheduling in Open Systems

, 2015
Although many cyber-physical systems are both mixed-criticality system and compositional system, there are little work on intersection of mixed-criticality system and compositional system.
Lee, Insup, Chwa, Hoon Sung, Shin, Insik, Easwaran, Arvind, Lee, Jaewoo   +4 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Sustainability in Mixed-Criticality Scheduling

, 2017
Sustainability is a formalization of the requirement for scheduling algorithms and schedulability tests that a system deemed to be correctly schedulable should remain so if its runtime behavior is better than anticipated.
Sruti, Sai, Baruah, Sanjoy K., Guo, Zhishan, Ward, Bryan C.   +3 more
core  

Mixed Criticality on Multicore / Manycore Platforms (Dagstuhl Seminar 17131)

, 2017
International audienceThis report provides an overview of the discussions, the program and the outcomes of the second Dagstuhl Seminar on Mixed Criticality on Multicore/Manycore Platforms.
Cucu-Grosjean, Liliana, Baruah, Sanjoy, K., Stephenson, Zoe, Davis, Robert   +3 more
core   +2 more sources