Results 31 to 40 of about 2,721 (244)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Utilization-Based Safety Aware Scheduling of Mixed-Criticality Real-Time System With Gradual Performance Degradation

IEEE Access
Mixed-criticality (MC) systems have become indispensable in managing diverse tasks within unified computational environments, particularly in complex embedded systems like those in the automotive and avionics industries.
Xinyang Dong, Wang Yi
doaj   +1 more source

Hypervisor-Based Multicore Feedback Control of Mixed-Criticality Systems

IEEE Access, 2018
One of the most promising approaches to mixed-criticality systems is the use of multi-core execution platforms based on a hypervisor. Several successful EU Projects are based on this approach and have overcome some of the difficulties that this approach ...
Alfons Crespo, Patricia Balbastre, Jose Simo, Javier Coronel, Daniel Gracia-Perez, Philippe Bonnot   +5 more
doaj   +1 more source

RTOS Support for Multicore Mixed-Criticality Systems [PDF]

2012 IEEE 18th Real Time and Embedded Technology and Applications Symposium, 2012
Mixed-criticality scheduling algorithms, which attempt to reclaim system capacity lost to worst-case execution time pessimism, seem to hold great promise for multi core real-time systems, where such loss is particularly severe. However, the unique nature of these algorithms gives rise to a number of major challenges for the would-be implementer.
Jonathan L. Herman, Christopher J. Kenna, Malcolm S. Mollison, James H. Anderson, Daniel M. Johnson 0004   +4 more
openaire   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Performance-Based Scheduling in Distributed Mixed Criticality Systems

IEEE Access
With a focus on computationally intensive, distributed, and parallel workloads, scheduling in mixed-criticality distributed systems presents significant challenges due to shared memory and resources, as well as the diverse demands of tasks.
Amjad Ali, Saud Wasly, Asad Masood Khattak, Ihsan Ali, Shahid Iqbal, Bashir Hayat   +5 more
doaj   +1 more source

Risk-Aware Scheduling of Dual Criticality Job Systems Using Demand Distributions [PDF]

Leibniz Transactions on Embedded Systems, 2018
We pose the problem of scheduling Mixed Criticality (MC) job systems when there are only two criticality levels, Lo and Hi -referred to as Dual Criticality job systems- on a single processing platform, when job demands are probabilistic and their ...
Alahmad, Bader Naim, Gopalakrishnan, Sathish   +1 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source