Results 41 to 50 of about 105,111 (265)

Experimental Study on Cavitation Noise Characteristics of a Hydraulic Model of Mixed-Flow Pump

IEEE Access, 2023
In order to investigate the characteristics of the cavitation noise of the hydraulic model of a mixed-flow pump, the noise variation law at the inlet and outlet four times the pipe diameter under different operating conditions of each effective ...
Tengyan Liu, Jianshen Zhu, Zonglong Wang, Haohan Geng, Hualun Zhu   +4 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The Impact of Pump Cavity Gaps on the Flow Characteristics of Helical Mixed-Flow Pumps

Actuators
The performance of pump-jet propulsion systems is critically important in defense and marine applications. However, their optimization has encountered bottlenecks due to a lack of theoretical understanding of underlying flow mechanisms.
Wei Han, Yucheng Chen, Tongqing Xue, Pengzheng Lei   +3 more
doaj   +1 more source

Energy Performance and Radial Force of a Mixed-Flow Pump with Symmetrical and Unsymmetrical Tip Clearances

Energies, 2017
The energy performance and radial force of a mixed flow pump with symmetrical and unsymmetrical tip clearance are investigated in this paper. As the tip clearance increases, the pump head and efficiency both decrease.
Yue Hao, Lei Tan, Yabin Liu, Yun Xu, Jinsong Zhang, Baoshan Zhu   +5 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Influence of Spanwise Distribution of Impeller Exit Circulation on Optimization Results of Mixed Flow Pump

Applied Sciences, 2021
The spanwise distribution of impeller exit circulation (SDIEC) has an important influence on the performance of the impeller. To quantitatively study the influence of SDIEC on optimization results, a comprehensive optimization system composed of the ...
Mengcheng Wang, Yanjun Li, Jianping Yuan, Fareed Konadu Osman   +3 more
doaj   +1 more source

The Mechanism of Air Blocking in the Impeller of Multiphase Pump

Separations
The exploitation and transportation of deep-sea and remote oil and gas fields have risen to become important components of national energy strategies. The gas–liquid separation and gas blocking caused by the large density difference between the gas and ...
Sicong Zhang, Wei Han, Tongqing Xue, Pan Qiang, Rennian Li, Jiandong Mi   +5 more
doaj   +1 more source

Hydrodynamic Characteristic Analysis and NSGA-II Optimization of a Vacuum Fish Pump

Journal of Marine Science and Engineering, 2023
The fish pump is an important piece of power equipment for aquaculture, especially for deep-sea engineering vessels and cage culture. Fish pump research focuses on reducing fish body damage, improving survival rates, and increasing fish lifting ...
Yang Hong, Ye Zhu, Chenglin Zhang, Meng Yang, Tao Jiang   +4 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source