Results 181 to 190 of about 2,429,084 (223)

Reproductive Donors' Needs and Preferences: A Mixed-methods Systematic Review. [PDF]

Int J Community Based Nurs Midwifery
Iranifard E, Latifnejad Roudsari R, Amirian M, Ebrahimzadeh Zagami S.   +3 more
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Students' Perceptions of Learning Environment in a Medical College in Mangalore, India: A Mixed-Methods Study. [PDF]

Cureus
Adhikari S, Naik P, Ismail IM, T M R, Khan M, Suresh K.   +5 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Perception of AI Symptom Models in Oncology Nursing: Mixed Methods Evaluation Study. [PDF]

JMIR Nurs
Nicholson B, Sloss EA, Smiley A, Finkelstein J, Mooney K.   +4 more
europepmc   +1 more source

Vietnamese University Students' Perceptions and Attitudes Toward Participation in Clinical Research: Mixed Methods Study. [PDF]

J Particip Med
Le Phuong C, Pham-Tram V, Huynh Thuy Phuong H, Thi Hoai Tam D, Minh Nguyet N, Dinh The T, Nguyen Thi Van T, Nguyen Thi Thu H, Vu Duy K, Vu Bao H, Do Van D, Tran TD, Wills B, Van Nuil JI, Kestelyn E.   +14 more
europepmc   +1 more source

Development and Validation of a Culturally Adapted Patient-Reported Experience Measure for Diabetes Care in Thailand: Mixed-Methods Study. [PDF]

Health Expect
Tint SS, Buawangpong N, Jiraporncharoen W, Oo MZ, Wiwatkunupakarn N, Rerkasem K, Kulprachakarn K, Chuljerm H, O'Brien TE, Mathur R, Rawdaree P, Angkurawaranon C.   +11 more
europepmc   +1 more source

Impact of epilepsy on people experiencing homelessness: A mixed-methods study. [PDF]

Epilepsia
Lucey H, Anderson C, McDermott R, Forde S, Sears J, Synnott C, Doherty CP, Doran E, Ní Cheallaigh C, Richard G.   +9 more
europepmc   +1 more source