Results 191 to 200 of about 2,542,204 (245)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

Adolescents' Strategies to Manage Mental Health Challenges In and After the Pandemic: Two Mixed-Methods Studies. [PDF]

open access: yesRes Child Adolesc Psychopathol
Huizenga HM   +4 more
europepmc   +1 more source

Alignment Between Cardiologists and AI-Driven Diagnostic Systems: Mixed Methods Study. [PDF]

open access: yesJ Med Internet Res
Mahdavi M   +5 more
europepmc   +1 more source

Feasibility and acceptability of ExerciseGuideUK for those living with and beyond lung cancer: a mixed methods study. [PDF]

open access: yesSupport Care Cancer
Curry J   +6 more
europepmc   +1 more source

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