Results 91 to 100 of about 771,922 (316)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Spin down of the core rotation in red giants

, 2012
The space mission Kepler provides us with long and uninterrupted photometric time series of red giants. We are now able to probe the rotational behaviour in their deep interiors using the observations of mixed modes.
Barban, C., Beck, P. G., Belkacem, K., Bloemen, S., De Ridder, J., Deheuvels, S., Elsworth, Y., Garcia, R. A., Goupil, M. J., Hekker, S., Kallinger, T., Klaus, T. C., Li, J., Marques, J. P., Mathur, S., Morris, R. L., Mosser, B., Ouazzani, R. M., Pinsonneault, M., Samadi, R., Stello, D.   +20 more
core   +3 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

A Digital Image Denoising Algorithm Based on Gaussian Filtering and Bilateral Filtering

ITM Web of Conferences, 2018
Bilateral filtering has been applied in the area of digital image processing widely, but in the high gradient region of the image, bilateral filtering may generate staircase effect. Bilateral filtering can be regarded as one particular form of local mode
Piao Weiying, Yuan Yibao, Lin Haijun
doaj   +1 more source

A Novel (DDCC-SFG)-Based Systematic Design Technique of Active Filters [PDF]

, 2013
This paper proposes a novel idea for the synthesis of active filters that is based on the use of signal-flow graph (SFG) stamps of differential difference current conveyors (DDCCs).
Fakhfakh, M., Pierzchala, M.
core   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Design of Compact Bandpass Filters Using Novel Dual-Mode Dielectric Patch Resonator

IEEE Access, 2018
This paper introduces a new dual-mode dielectric patch resonator (DPR), which consists of a thin square dielectric patch with high permittivity and a low-permittivity substrate with bottom ground plane.
Jian-Xin Chen, Yun-Li Li, Wen-Wen Yang, Zhi-Hua Bao   +3 more
doaj   +1 more source

Tracking shocked dust: state estimation for a complex plasma during a shock wave

, 2011
We consider a two-dimensional complex (dusty) plasma crystal excited by an electrostatically-induced shock wave. Dust particle kinematics in such a system are usually determined using particle tracking velocimetry.
Durniak, Céline, Oxtoby, Neil P., Ralph, Jason F., Samsonov, Dmitry   +3 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source