Results 101 to 110 of about 923,003 (329)
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
East European Journal of Physics, 2016 On the basis of the Navier-Stokes equations in the Boussinesq approximation in the linear approximation the classical problem of Rayleigh, dedicated to the study of stable stationary solutions to the horizontal plane layer of a viscous, incompressible ...
O. L. Andreeva, V. I. Tkachenko
doaj
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Rényi entropies for one-dimensional quantum systems with mixed boundary conditions
SciPost PhysicsWe present a general method for calculating Rényi entropies in the ground state of a one-dimensional critical system with mixed open boundaries, for an interval starting at one of its ends.
Benoit Estienne, Yacine Ikhlef, Andrei Rotaru
doaj +1 more source
Existence of Positive Solution to Schrödinger-type Semipositone Problems with Mixed Nonlinear Boundary Conditions [PDF]
, 2020 Eunkyung Ko, Eun Kyoung Lee, Inbo Sim
openalex +1 more source
Nonlinear Katugampola Fractional Differential Equation with Mixed Boundary Conditions
Tatra Mountains Mathematical Publications, 2023 Abstract This paper discusses the existence and uniqueness of solutions for a class of nonlinear fractional differential equations with a mixed fractional boundary value using Banach and Schaefer fixed-point theorems. The examples illustrating the main results are given.
openaire +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Role of thermophoresis on unsteady/steady mixed convective flow in a vertical channel having convective boundary conditions [PDF]
, 2022 Basant K. Jha, Hadiza Nass Sani
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Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source