Results 91 to 100 of about 923,003 (329)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

A Second-Order Boundary Value Problem with Nonlinear and Mixed Boundary Conditions: Existence, Uniqueness, and Approximation

Abstract and Applied Analysis, 2010
A second-order boundary value problem with nonlinear and mixed two-point boundary conditions is considered, Lx=f(t,x,x′), t∈(a,b), g(x(a),x(b),x′(a),x′(b))=0, x(b)=x(a) in which L is a formally self-adjoint second-order differential operator.
Zheyan Zhou, Jianhe Shen
doaj   +1 more source

Analytic and Monte Carlo Approximations to the Distribution of the First Passage Time of the Drifted Diffusion with Stochastic Resetting and Mixed Boundary Conditions [PDF]

, 2023
Juan Magalang, Riccardo Turin, Javier Aguilar, Laetitia Colombani, Daniel Sánchez‐Taltavull, Riccardo Gatto   +5 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

ELEMENTARY CONVECTION CELL IN THE HORIZONTAL LAYER OF VISCOUS INCOMPRESSIBLE LIQUID WITH RIGID AND MIXED BOUNDARY CONDITIONS

East European Journal of Physics, 2015
The result of experimental study of convection cells formation of vacuum oil with mixed boundary conditions is presented. The adding small amounts of dispersed phase (aluminum powder) the viscosity and density of the oil didn’t change and under such ...
О. L. Patochkina, B. V. Borts, V. I. Tkachenko   +2 more
doaj  

Nonlinear eigenvalue problems with mixed boundary conditions

Journal of Mathematical Analysis and Applications, 1974
AbstractSome of the properties of the upper bound of the spectrum of a quasilinear eigenvalue problem, subject to a positivity requirement, are derived. It is shown that, as a function of the surface heat-transfer coefficient, this parameter is a continuous, monotonic increasing function and is bounded above.
Heath, J.M., Wake, G.C.
openaire   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A rigorous formulation of drain boundary conditions for groundwater flow modeling in geotechnical engineering

Journal of Rock Mechanics and Geotechnical Engineering
Drains play an important role in seepage control in geotechnical engineering. The enormous number and one-dimensional (1D) geometry of drainage holes make their nature difficult to be accurately modeled in groundwater flow simulation.
Wan-Jun Lei, Yi-Feng Chen, Wang Ren, Yunrui Deng, Ran Hu, Zhibing Yang   +5 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Boundary Element Method for the Mixed BBM-KdV Equation Compared to Non Standard Boundary Conditions

, 2021
Mostafa Abounouh, Hassan Al-Moatassime, Sabah Kaouri, Youssef Ouakrim   +3 more
openalex   +2 more sources