Results 41 to 50 of about 8,204,733 (251)

Transverse myelopathy complicating mixed connective tissue disease

, 1995
We report the case of a 46-year-old female patient with transverse myelitis complicating mixed connective tissue disease (MCTD). She responded well to steroid and immunosuppressive therapy.
Lau, CS, C.S. Lau, C.C. Mok, Mok, CC
core   +1 more source

Evolution of Mixed Connective Tissue Disease in 7 Years Old Child: Clinical Case [PDF]

, 2020
Background. Mixed connective tissue disease (Sharp syndrome) is the rare chronic autoimmune pathology combining various features of systemic lupus erythematosus, systemic scleroderma, rheumatoid arthritis, dermatomyositis and high antibody titer to ...
Dina R. Sabirova, Natalya N. Firsova, Liliya R. Khusnutdinova, Khakim M. Vakhitov, Anna A. Kucheryavaya, Dinara I. Sadykova, Tamara P. Makarova   +6 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Fifteen-Year Experience of Pediatric-Onset Mixed Connective Tissue Disease

, 2011
The aim of this study was to investigate the initial clinical manifestations, laboratory data, complications, and outcomes of patients with pediatric-onset mixed connective tissue disease (MCTD) in Taiwan.
俞欣慧;王麗潔;李志鴻;江伯倫, YU, HSIN-HUI;WANG, LI-CHIEH;LEE, JYH-HONG;CHIANG, BOR-LUEN   +1 more
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Correlation Between Serum Tumor Marker Levels and Connective Tissue Disease-Related Interstitial Lung Disease

, 2021
Yunqi Bao,1 Wei Zhang,1 Dandan Shi,2 Weili Bai,1 Dongdong He,1 Dan Wang1 1Department of Rheumatology, Xi’an Fifth Hospital, Xian, 710000, Shaanxi, People’s Republic of China; 2Department of Radiology, Xi’an Fifth Hospital, Xian, 710000,
Zhang W, He D, Bao Y, Wang D, Shi D, Bai W   +5 more
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Heritable connective tissue disorders in childhood : increased fatigue, pain, disability and decreased general health

, 2021
Heritable Connective Tissue Disorders (HCTD) show an overlap in the physical features that can evolve in childhood. It is unclear to what extent children with HCTD experience burden of disease.
Alsem, Mattijs W., Malfait, Fransiska, Braam, Katja, Loeys, Bart L., van Rossum, Marion A. J., Malfait, FransiskaGE31UZGent0019932778548010014726390000-0002-5010-0304FE9977EC-F0ED-11E1-A9DE-61C894A0A6B4, Van der Looven, RuthGE37UZGent0019943687028020033645220000-0003-4172-8658FF6A5948-F0ED-11E1-A9DE-61C894A0A6B4, Baars, Marieke J.H., Buizer, Annemieke, I, Stoelinga, Femke, van Rossum, Marion A.J., Oosterlaan, Jaap, Krapels, Ingrid P. C., Kempers, Marlies J. E., Krapels, Ingrid P.C., Loeys, Bart, Engelbert, Raoul H.H., Engelbert, Raoul H. H., Dulfer, Eelco, de Boer, Rosa, Hilhorst-Hofstee, Yvonne, Warnink-Kavelaars, Jessica, Rombaut, Lies, Menke, Leonie A., Kempers, Marlies J.E., Baars, Marieke J. H., Rombaut, LiesUZGent000080741483802000058236974628529802F5A6C73E-F0ED-11E1-A9DE-61C894A0A6B4, de Koning, Lisanne E., Van der Looven, Ruth   +28 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source