Results 31 to 40 of about 288,106 (215)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Numerical Investigation of Wind Turbine Airfoil Icing and Its Influencing Factors under Mixed-Phase Conditions

Energies
Icing is a popular research area in wind energy, and the icing problem of the supercooled droplet–ice crystal mixed-phase condition is one of the new challenges.
Xiang Wang, Yiyao Ru, Huanyu Zhao, Zhengzhi Wang   +3 more
doaj   +1 more source

Crystal structure of a mixed chain diacylglycerol, 1-stearoyl-3-oleyl-glycerol.

Journal of Lipid Research, 1996
Diacylglycerols composed of one saturated and one unsaturated chain make up the hydrophobic core of many biological membranes. We report here the first crystalline structure of such a mixed chain diacylglycerol. The mixed chain diacylglycerol, 1-stearoyl-
M Goto, K Honda, L Di, D M Small
doaj   +1 more source

Promoting effect of Rh on the activity and stability of Pt-based methane combustion catalyst in microreactors

Catalysis Communications, 2021
For the combustion of methane, a partial replacement of platinum by rhodium leads to a significantly improved light-off behavior of the corresponding mixed Pt-Rh/γ-Al2O3 catalysts compared to a catalyst containing only Pt supported on γ-Al2O3. For all Pt-
Stefan Neuberg, Helmut Pennemann, Vetrivel Shanmugam, Ralf Zapf, Gunther Kolb   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Study on the properties of modified starch and its feasibility in crystal dumpling skins

BIO Web of Conferences, 2021
Four kinds of modified starches that are expected to improve the quality of crystal dumpling skins were selected, namely Potato acetate starch, Potato hydroxypropyl starch, Octenyl succinate starch sodium, Acetate cassava starch.
Jingwen Wang, Melnyk Oksana, Ihnatieva Olha   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Mixed low‐dimensional metal halide perovskite single crystal for low‐detection‐limit x‐ray detection via oriented ion migration

InfoMat
Low‐dimensional metal halide perovskites exhibit exceptional photoelectronic properties and intrinsic stability, positioning them as a promising class of semiconductor materials for light‐emitting devices and photodetectors.
Xuefang Lu, Richeng Lin, Ying Ding, Man Xia, Wei Zheng, Feng Huang   +5 more
doaj   +1 more source

A new method for the rapid measurement of cholesterol crystallization in model biles using a spectrophotometric microplate reader

Journal of Lipid Research, 1997
Measurements of the cholesterol crystal observation time, and particularly the crystal growth rate in model biles, are important in biliary pathophysiology.
G J Sömjen, Y Ringel, F M Konikoff, R Rosenberg, T Gilat   +4 more
doaj   +1 more source