Results 51 to 60 of about 288,106 (215)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Crystal structure of μ-cyanido-1:2κ2N:C-dicyanido-1κC,2κC-bis(quinolin-8-amine-1κ2N,N′)-2-silver(I)-1-silver(II): rare occurrence of a mixed-valence AgI,II compound

Acta Crystallographica Section E: Crystallographic Communications, 2015
The title dinuclear complex, [Ag2(CN)3(C9H8N2)2], may be considered as an AgII compound with the corresponding metal site coordinated by two bidentate quinolin-8-amine molecules, one cyanide group and one dicyanidoargentate(I) anion, [Ag(CN)2]−.
Zouaoui Setifi, Sylvain Bernès, Olivier Pérez, Fatima Setifi, Djamil-Azzeddine Rouag   +4 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Crystal structure of dichlorido[2-(diphenylphosphanyl)-3,4,5,6-tetrafluorobenzene-1-thiolato-κ2P,S]gold(III)

Acta Crystallographica Section E: Crystallographic Communications, 2015
The title compound, [Au(C18H10F4PS)Cl2], crystallizes as neutral molecules, with the AuIII atom coordinated by two Cl atoms and by the P and S atoms of the bidentate phosphanyl thiolate ligand, in a slightly distorted square-planar environment.
Peter W. R. Corfield, Mary Bailey
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Crystal structure of mixed compound Cu2(D-Ala) (D-Ser)(L-Ser)2

Moldavian Journal of the Physical Sciences, 2006
The crystal structure of mixed cooper(II) compound Cu2(D-Ala)(D-Ser)(L-Ser)2, that contains the residues of alanine (Ala) and serine (Ser) in proportion 1:3 in its composition, was determined by electron diffraction technique.
Diacon, Ion, Donu, Sofia, Ciapurina, Liudmila   +2 more
doaj  

Mixed occupancy: the crystal structure of scheelite-type LiLu[MoO4]2

Acta Crystallographica Section E: Crystallographic Communications
Coarse colorless single crystals of lithium lutetium bis[orthomolybdate(VI)], LiLu[MoO4]2, were obtained as a by-product from a reaction aimed at lithium derivatives of lutetium molybdate.
Ingo Hartenbach, Robin F. Hertweck
doaj   +1 more source

Intercomparison of cloud model simulations of Arctic mixed-phase boundary layer clouds observed during SHEBA/FIRE-ACE

Journal of Advances in Modeling Earth Systems, 2011
An intercomparison of six cloud-resolving and large-eddy simulation models is presented. This case study is based on observations of a persistent mixed-phase boundary layer cloud gathered on 7 May, 1998 from the Surface Heat Budget of Arctic Ocean (SHEBA)
Mikhail Ovchinnikov, Ben Shipway, Yali Luo, Jerry Y. Harrington, Tempei Hashino, Jiwen Fan, Ann M. Fridlind, Gijs de Boer, Alexander Avramov, Andrew S. Ackerman, Hugh Morrison, Paquita Zuidema   +11 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source