Results 111 to 120 of about 222,950 (183)

Transplacental induction of mixed-function oxygenases in extra-hepatic tissues by 2,3,7,8-tetrachlorodibenzo-p-dioxin

Biochemical Pharmacology, 1977
Abstract Treatment of pregnant rats with 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD) resulted in a dose-dependent induction of a mixed-function oxidase system in fetal and maternal extra-hepatic tissues. At doses of 6 μmg/kg, aryl hydrocarbon hydroxylase (AHH) activity was increased 24-, 22- and 4-fold in fetal lung, kidney and skin, respectively ...
D L, Berry, T J, Slaga, N M, Wilson, P K, Zachariah, M J, Namkung, W M, Bracken, M R, Juchau   +6 more
openaire   +3 more sources

Responsiveness of Carmustine (BCNU) Treated Mice to Induction and Inhibition of Mixed Function Oxygenases

Journal of Urology, 1982
The responsiveness of BCNU treated mice to phenobarbital (Pb) induction of hepatic microsomal mixed function oxygenase (MFO) activity was studied. BCNU (30 mg/kg ip) produced significant (P less than 0.05) decreases in cytochrome P-450, total ethylmorphine metabolism (TEM) and ethylmorphine N-demethylase (EMN) by 21 days after treatment.
V L, Wilson, R E, Larson
openaire   +3 more sources

The interplay between mixed function oxygenases and DNA alteration under PAH pollution

Marine Environmental Research, 1985
Abstract Our experience in DNA alteration assessment tells us that aquatic vertebrates, in general, and also some of the invertebrates, by living in polluted areas acquire altered DNA; DNA alterations being defined either as single-strand breaks, and/or alkali sensitive or single-strand specific nuclease-cleavable sites (sse).
R.K. Zahn, J.J. Stüber, M. Reitz, C. Emmig, U. Jannek, B. Kurelec   +5 more
openaire   +2 more sources

Effects of horminone on liver mixed function mono-oxygenases and glutathione enzyme activities of Wistar Rat

Journal of Ethnopharmacology, 1997
The present study reports on the effects of horminone on serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, on hepatic cytochrome P450 (P450) and cytochrome b5 (cyt b5) contents and on the activities of NADPH-cytochrome P450 reductase (NR), mixed function mono-oxygenases (MFO), glutathione-S-transferase (GST) and ...
R, Ferreira, F, Candeias, F, Simões, J, Nascimento, J, Cruz Morais   +4 more
openaire   +3 more sources

A bleached-kraft mill effluent fraction causing induction of a fish mixed-function oxygenase enzyme

Environmental Toxicology and Chemistry, 1996
Abstract Pulp mill effluents contain a myriad of chemicals that have the potential to cause deleterious effects on aquatic biota in receiving waters. Some of these chemicals evoke an acute lethal response of exposed biota while others evoke sublethal responses.
B. Kent Burnison, Peter V. Hodson, Donna J. Nuttley, Sue Efler   +3 more
openaire   +2 more sources

Mixed Function Oxygenase Induction in Pre- and Post-Spawn Herring (Clupea pallasi) by Petroleum Hydrocarbons

Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, 1997
We compared the uptake of water-accommodated fractions of Alaska North Slope crude oil in pre- and post-spawn herring (Clupea pallasi) and the resulting induction of mixed function oxygenase activity. Both groups of herring accumulated significant quantities of polycyclic aromatic hydrocarbons in muscle tissue.
Robert E Thomas, Mark G Carls, Stanley D Rice, Lamia Shagrun   +3 more
openaire   +2 more sources

Comparison of liver mixed-function oxygenase and antioxidant enzymes in vertebrates

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2004
We performed a comparative analysis of cytochrome P450, cytochrome b5, MFO associated enzymes and cytosolic antioxidant enzymes in hepatic microsomes and cytosolic fractions prepared from five animal species representing three vertebrate classes living in tropical conditions (Brazil).
Thomaz A A, Rocha-e-Silva, Marcelo M, Rossa, Francisco T, Rantin, Takako, Matsumura-Tundisi, Jose G, Tundisi, Igor A, Degterev   +5 more
openaire   +2 more sources

Mixed-function oxygenase system and benzo[a]pyrene metabolism in echinoderms

Marine Environmental Research, 1989
Abstract A comparative study on the presence of a mixed-function oxygenase (MFO) system was carried out on four echinoderm species: the asteroids Asterias rubens and Marthasterias glacialis , an echinoid Echinus esculentus and a holothurian Holothuria forskali . In A.
Pieter J. den Besten, David R. Livingstone   +1 more
openaire   +1 more source

Review and perspective on the use of mixed-function oxygenase enzymes in biological monitoring

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1987
It is often suggested that changes in simple biochemical/physiological responses may be useful for predicting the impacts of pollutants at population and community levels of biological organization. There are serious conceptual constraints to such a thesis and its seems likely that such simple responses can go no further than serving as early warning ...
J F, Payne, L L, Fancey, A D, Rahimtula, E L, Porter   +3 more
openaire   +2 more sources

Presence of mixed function oxygenase in some marine invertebrates

Thalassia Jugoslavica, 1983
We could confirm MFO activity in crabs at the levelswhich are low compared to the activity levels found in vertebrates. MFO inducibility by Diesel-2 oil and benzo(a)pyrene was demonstrated in crab Pilumnus spinifer.
Kurelec, Branko, Batel, Renato, Bihari, Nevenka   +2 more
openaire   +2 more sources