Results 121 to 130 of about 11,772 (251)

Hypoxia regulates epithelial to mesenchymal transition-associated genes in human trophoblast cells by modulating DNA methylation. [PDF]

PLoS One
Choudhury J, Dhole B, Aggarwal K, Singh P, Jala MA, Pandey D, Chaturvedi PK, Gupta S.   +7 more
europepmc   +1 more source

Bioconversion of carotenoids into high‐value crocins using a marine sponge carotenoid cleavage dioxygenase

New Phytologist, Volume 250, Issue 5, Page 3230-3246, June 2026.
Summary Carotenoids and apocarotenoids are widespread specialized metabolites, yet animals, including sponges, lack the ability to synthesize carotenoids de novo and must obtain them from dietary or microbial sources. The roles of carotenoid cleavage dioxygenases (CCDs) in marine animals remain largely unexplored. A CCD from the marine sponge Suberites
Elena Moreno‐Giménez, Lucía Morote, Alberto José López Jiménez, Eduardo Parreño, Jian You Wang, Matteo Nava, Carolina Aguado, Rafael Luján, Salim Al‐Babili, Gianfranco Diretto, Oussama Ahrazem, Lourdes Gómez‐Gómez   +11 more
wiley   +1 more source

The gut microbiota mediates epoxy eicosanoid metabolism in the colon. [PDF]

J Biol Chem
Jing N, Edin ML, Wang Y, Yang J, Lih FB, Yeliseyev V, Liu F, Ding Y, Zeldin DC, Zhang G.   +9 more
europepmc   +1 more source

Guard cell photorespiration controls stomata behavior and development

New Phytologist, Volume 250, Issue 5, Page 3182-3196, June 2026.
Summary Photorespiration is traditionally viewed as a limitation to photosynthetic efficiency. However, it is mandatory for safeguarding the Calvin–Benson–Bassham cycle from inhibitory byproducts through Rubisco‐mediated oxidative misfire and is tightly integrated with primary metabolism.
Hu Sun, Inken Thiemann, Nils Schmidt, Johannes Kromdijk, Tracy Lawson, Martin Hagemann, Stefan Timm   +6 more
wiley   +1 more source

Unexpected Dual Function of Plant YUCCA Enzymes Links Chlorophyll Catabolism to Auxin Homeostasis. [PDF]

Angew Chem Int Ed Engl
Rütschlin S, Zhang L, Karg CA, Zwerger M, Gostner JM, Moser S, Teufel R.   +6 more
europepmc   +1 more source

Loss of qE Does Not Necessarily Lead to Photoinhibition: Sustained Non‐Photochemical Quenching in the Absence of PsbS and Zeaxanthin

Plant, Cell &Environment, Volume 49, Issue 6, Page 3405-3425, June 2026.
ABSTRACT Photosynthetic light‐harvesting complexes mediate light absorption and energy dissipation. By modulating the photosystems' absorption cross‐section, they affect both photosynthetic activity and non‐photochemical quenching (NPQ). These processes are often studied by spectrally integrated chlorophyll fluorescence, masking their associated ...
Maximiliano Cainzos, Chen Hu, Maria Dolores Pissolato, Nazeer Fataftah, Sanchali Nanda, Stefan Jansson   +5 more
wiley   +1 more source

Heme Oxygenase-Like Metalloenzymes. [PDF]

Annu Rev Biochem
Pope SR, McBride MJ, Nair MA, Salas-Solá XE, Krebs C, Bollinger JM, Boal AK.   +6 more
europepmc   +1 more source

Identification of 2‐Substituted‐3‐Hydroxy‐2,3‐Dihydroquinazolin‐4(1H) Ones as Cell‐Active Inhibitors of KDM4A Lysine Demethylase

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
A novel 3‐hydroxy‐2,3‐dihydroquinazolinone scaffold is identified as a cell‐active KDM4A inhibitor through an orthogonal screening cascade minimizing assay interference. Integrated biochemical, biophysical, and proteomic validation reveals compound 6i as a bona fide binder that increases H3K9 methylation in cells, highlighting both a promising ...
Alessandra Feoli, Amodio Luca Balzano, Ida Pacilio, Alessandra Cipriano, Roman Belle, Giacomo Pepe, Manuela Giovanna Basilicata, Pietro Campiglia, Fabrizio Micheli, Akane Kawamura, Ciro Milite, Sabrina Castellano, Axel Imhof, Gianluca Sbardella   +13 more
wiley   +1 more source

Mechanistic study on how the Tet1/ARF-p53 pathway affects idiopathic pulmonary fibrosis through macrophage polarization. [PDF]

J Transl Med
Zhang P, Guo X, Wang T, Wang S.
europepmc   +1 more source

Synthesis of Amines for Active Pharmaceutical Ingredients Using the Whole‐Cell Factory Saccharomyces Cerevisae

ChemBioChem, Volume 27, Issue 9, 14 May 2026.
This review highlights advances in engineering Saccharomyces cerevisiae for the sustainable biocatalytic production of pharmaceutically relevant amines, amino alcohols, amino acids, and complex alkaloids. It focuses on strategies to increase productivity, including enhanced enzyme expression, cofactor regeneration, precursor channeling, pathway ...
Natalia Kwiatos, Stephen Ossel, Francesco G. Mutti   +2 more
wiley   +1 more source