Results 111 to 120 of about 6,626 (210)

Symbiont-mediated mechanisms of insecticide resistance in insects. [PDF]

J Insect Sci
Lv C, Xia Q, Yan S.
europepmc   +1 more source

Dexpanthenol Attenuates Methotrexate‐Induced Nephrotoxicity Through Modulation of NF‐κB–Mediated Inflammation and SIRT1/PGC‐1α–NRF2/HO‐1–Associated Oxidative Stress Pathways

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Graphical abstract depicting the protective role of DEX against MTX‐induced nephrotoxicity. MTX exposure activates NF‐κB, leading to upregulation of TNF‐α and downstream apoptotic mediator Cas‐3, which collectively drive inflammation, apoptosis, and renal tissue damage. Simultaneously, MTX suppresses protective regulators SIRT1, PGC‐1α, NRF2, and HO‐1,
Atila Altuntas, Halil Asci, Esma Selcuk, Huzeyfe Karaosman, Osman Aydin, Ilter Ilhan, Sefa Alperen Ozturk, Ozlem Ozmen   +7 more
wiley   +1 more source

Molecular Basis of α-Glycine C-H Activation by a Nonheme Fe(II)/2-Oxoglutarate Dioxygenase. [PDF]

Biochemistry
Chen M, Wanniarachchi TN, Caranto JD, Seabra G, Bruner SD, Ding Y.   +5 more
europepmc   +1 more source

Induction of liver mixed function oxygenase system by beta- & gamma-hexachlorocyclohexane.

Indian journal of biochemistry & biophysics, 1984
K, Srinivasan, R, Radhakrishnamurty
openaire   +1 more source

Methotrexate Alters Nrf2/HO‐1 Protein Expression and Intrinsic Apoptosis‐Associated Protein Responses in OVCAR‐3 Ovarian Cancer Cells: Differential Modulation by Antioxidant Compounds

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Methotrexate (MTX) altered oxidative stress parameters, reduced Nrf2 and HO‐1 protein expression, increased intrinsic apoptosis‐associated protein markers, and decreased cell viability in OVCAR‐3 cells. Antioxidant co‐treatment partially modulated these protein responses and oxidative stress parameters.
Oya Korkmaz
wiley   +1 more source

Promotion of shade avoidance by BBX5 involves activation of PIF4 along with auxin biosynthetic and signaling genes. [PDF]

PLoS Genet
Zhao F, Yang R, Song Z, Bian Y, Xiao Y, Xu D.   +5 more
europepmc   +1 more source

SIRT Family: Biological Functions and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang, Feng‐Li Jiang, Fang‐Yuan Zhang, Dong‐Hui Huang, Xiao‐Ying Li, Song Gao, Hua You, Qi‐Jun Wu, Huan‐Huan Chen, Ting‐Ting Gong   +9 more
wiley   +1 more source

Decoding color variation: genome-wide characterization and expression analysis of pigment pathways in Neocaridina denticulata. [PDF]

BMC Genomics
Bai S, Ma Z, Gu R, Yang X, Sun Y, Hu J, Bao Z, Qu Z.   +7 more
europepmc   +1 more source

Macrophage: Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
Macrophages are sentinel innate immune cells that arise from embryonic precursors and bone marrow monocytes, displaying a functional continuum that transcends the classical M1 (pro‐inflammatory)/M2 (anti‐inflammatory) dichotomy. Under homeostatic conditions, balanced M1/M2 polarization preserves tissue integrity by coordinating immune surveillance ...
Bihang Sun, Linqing Wen, Shiyun Tang, Lu Liu, Nianzhi Chen   +4 more
wiley   +1 more source

mRNA expression of DNA methylation machinery genes in periapical granuloma and their potential relationship with periapical wound healing. [PDF]

Sci Rep
Ahmed MA, Nazim F.
europepmc   +1 more source