Results 141 to 150 of about 6,626 (210)

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, Volume 59, Issue 8, August 2026.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

The Arsenal of Aromatic Degrading Bacteria: How They Sense, Chase, Adapt and Destroy Environmental Pollutants. [PDF]

Microb Biotechnol
Phale PS, Dhamale T, Subhash S.
europepmc   +1 more source

Inflammatory Cytokines Impair Glucagon Expression and Secretion in Pancreatic α‐Cells

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 7149-7160, August 2026.
ABSTRACT Aims Insulin resistance and obesity‐associated inflammation are key drivers in the pathogenesis of Type 2 diabetes mellitus (T2DM). Whilst inflammatory cytokines are well known to impair β‐cell function, their impact on pancreatic α‐cells and glucagon (GCG) regulation remains poorly understood. In this study, we investigated the effects of the
Caroline Bickelmann, Cedric Wilden, Leticia Prates‐Roma, Matthias W. Laschke, Emmanuel Ampofo, Selina Wrublewsky   +5 more
wiley   +1 more source

Derivatives of the Clinically Used HIF Prolyl Hydroxylase Inhibitor Desidustat Are Efficient Inhibitors of Human γ-Butyrobetaine Hydroxylase. [PDF]

J Med Chem
Corner TP, Tumber A, Salah E, Jabbary M, Nakashima Y, Schnaubelt LI, Basak S, Alshref FM, Brewitz L, Schofield CJ.   +9 more
europepmc   +1 more source

Human IDO2 exhibits unique binding affinities distinct to those of human IDO1

The FEBS Journal, Volume 293, Issue 15, Page 4533-4553, August 2026.
Although indoleamine 2,3‐dioxygenase 2 (IDO2) is highly homologous to IDO1, it displays markedly lower catalytic activity. We found that IDO2 binds L‐tryptophan (L‐Trp) in a flipped orientation stabilized by the IDO2‐specific residue His143. Replacement of His143 with the IDO1‐equivalent tyrosine restored an IDO1‐like binding mode and increased ...
Shunsuke Nogi, Ayumu Takahashi, So Murakami, Nami Adachi, Tina Fujimoto, Yohta Fukuda, Taku Yamashita, Tsuyoshi Inoue, Hirofumi Tsujino   +8 more
wiley   +1 more source

Disruption of carotenoid metabolism in cavefish via loss of beta-carotene oxygenase 2a. [PDF]

Curr Biol
Guerra DP, Bandara S, Leal F, Vasquez-Gross H, Petereit J, von Lintig J, Riddle MR.   +6 more
europepmc   +1 more source

Impact of the invasive diatom species Cymbella janischii on riverine microbial biofilm communities and a potential role of bacterially produced zeatin

Journal of Phycology, Volume 62, Issue 4, Page 1221-1239, August 2026.
Abstract The diatom Cymbella janischii is an invasive species in Japan, causing nuisance blooms by forming thick mats in rivers. To date, there are no documented studies on the microbiome associations in C. janischii mats or the processes that drive bloom formation.
Eldrin D. L. R. Arguelles, Kana Mugikura, Shinya Sato   +2 more
wiley   +1 more source

Ancestral Sequence Reconstruction of the Ethylene-Forming Enzyme. [PDF]

Biochemistry
Chatterjee S, Rankin JA, Farrugia MA, Delaney BJ, Pascual NS, VanAntwerp J, Woldring DR, Hu J, Hausinger RP.   +8 more
europepmc   +1 more source

Integrative taxonomy of Harveylithon (Corallinales, Rhodophyta) reveals three new species from Korea and expanded diversity in the northwestern Pacific

Journal of Phycology, Volume 62, Issue 4, Page 1392-1411, August 2026.
Abstract Non‐geniculate coralline genus Harveylithon includes 12 species worldwide. In this study, we propose three new species, Ha. koreanum sp. nov., Ha. longiforme sp. nov., and Ha. planiforme sp. nov., based on integrative molecular and morphological analyses.
Gwan Woung Kim, So Young Jeong, Boo Yeon Won, Suzanne Fredericq, Tae Oh Cho   +4 more
wiley   +1 more source

Phenylacetate Hydroxylase SsPhacA Modulates p-Coumaric Acid Accumulation to Regulate the Mating/Filamentation of Sporisorium scitamineum. [PDF]

Mol Plant Pathol
Xiong B, Zhang N, Guo Y, Lei Y, Wu J, Chang C, Cai E.   +6 more
europepmc   +1 more source