Results 121 to 130 of about 222,950 (183)

Responses of channel catfish to xenobiotics: Induction and partial characterization of a mixed function oxygenase

Archives of Environmental Contamination and Toxicology, 1983
The effects of the environmental pollutant benzo(a)pyrene (BP) were assessed on the hepatic mixed function oxygenase system (MFO) in the channel catfish,Ictalurus punctatus. Initially, the optimum conditions were established for measuring hepatic MFO in this species of fish.
S W, Fingerman, L A, Brown, M, Lynn, E C, Short   +3 more
openaire   +2 more sources

Sex differences in cytochrome P-450 and mixed-function oxygenase activity in gonadally mature trout

Biochemical Pharmacology, 1980
Abstract Levels of microsomal cytochrome P-450 and aminopyrine demethylase activity in liver and of cytochrome P-450 in kidney of gonadally mature rainbow and brook trout were markedly greater in males than in females. Similar differences appeared in hepatic microsomal NADH- but not in NADPH-cytochrome c reductase activity or cytochrome b 5 ...
J J, Stegeman, M, Chevion
openaire   +2 more sources

Mixed-function oxygenation of the lower fatty acyl residues. II. The kinetics of microsomal omega- and (omega - 1)-hydroxylation of N-(4-chlorophenyl)propanamide.

Drug Metabolism And Disposition, 1981
Investigation of the kinetics of microsomal omega- and (omega - 1)-hydroxylation of 4,'-chloropropionanilide with rabbit liver microsomes revealed normal Michaelis-Menten behavior for that form of cytochrome P-450 which catalyzes omega-hydroxylation, and
V. Apostolescu, W. Lenk
semanticscholar   +1 more source

Mixed-function oxygenase in juvenile rainbow trout exposed to hexachlorobenzene or 3, 3′, 4, 4′-tetrachlorobiphenyl

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1991
1. 3,3',4,4'-tetrachlorobiphenyl (PCB 77), but not hexachlorobenzene, induced liver microsomal cytochrome P-450 (Cyt P-450), ethoxycoumarin-O-deethylase (ECOD) and ethoxyresorufin-O-deethylase (EROD) in rainbow trout. Maximum induction was observed in a PCB 77 injected group of fish (1.0 mg/kg, i.p.
Tyle, Henrik, Egsmose, Mark, Harrit, Niels   +2 more
openaire   +2 more sources

Responses of mixed-function oxygenase and antioxidase enzyme system of Mytilus sp. to organic pollution

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1991
1. Mixed-function oxidase (MFO) system components (cytochrome P-450, "418-peak", cytochrome b5 and NADPH-cytochrome c(P-450) reductase) and inducible antioxidant enzymes (catalase, superoxide dismutase (SOD), glutathione peroxidase (GPX) and DT-diaphorase) has been determined in digestive glands of mussels (Mytilus galloprovincialis) collected from ...
C, Porte, M, Solé, J, Albaigés, D R, Livingstone   +3 more
openaire   +2 more sources

EFFECTS OF 7,12-DIMETHYLBENZ[a]ANTHRACENE ON IMMUNE FUNCTION AND MIXED-FUNCTION OXYGENASE ACTIVITY IN THE EUROPEAN STARLING

Environmental Toxicology and Chemistry, 1994
AbstractImmune function and hepatic MFO activity were examined in adult and nestling starlings administered a synthetic PAH, 7,12-dimethylbenz[a]anthracene (DMBA). Methods used to examine the starling immune system included immunopa-thology, macrophage phagocytosis, lymphocyte blastogenesis to concanavalin A, and hemagglutination of sheep erythrocytes (
Kimberly A. Trust, Michael J. Hooper, Anne Fairbrother   +2 more
openaire   +1 more source

Hepatic microsomal mixed function oxygenase: Enzyme multiplicity for the metabolism of carcinogens to DNA-binding metabolites

Biochemical and Biophysical Research Communications, 1974
Microsome-mediated metabolic activation of aflatoxin B1 (AFB1) and benzo[a]-pyrene (BP), as determined by the in vitro formation of DNA binding metabolites, was studied, using hepatic microsomes from untreated, phenobarbital (PB)-treated and 3-methylcholanthrene (MC)-treated male rats.
H L, Gurtoo, N, Bejba
openaire   +2 more sources

SEASONAL VARIATION IN THE MIXED-FUNCTION OXYGENASE SYSTEM AND ANTIOXIDANT ENZYMES OF THE MUSSEL MYTILUS GALLOPROVINCIALIS

Environmental Toxicology and Chemistry, 1995
Abstract Seasonal variations in the mixed-function oxygenase (MFO) system components (cytochrome P450, “418” peak, and NADPH-cytochrome c[P450] reductase) and antioxidant enzymes (catalase, superoxide dismutase [SOD], glutathione peroxidase [GPX], and DT-diaphorase) of the mussel Mytilus galloprovincialis have been evaluated.
Solé, Montserrat, Porte Visa, Cinta, Albaigés Riera, Joan   +2 more
openaire   +2 more sources

KINETICS OF MIXED FUNCTION OXYGENASE INDUCTION AND RETENE EXCRETION IN RETENE-EXPOSED RAINBOW TROUT (ONCORHYNCHUS MYKISS)

Environmental Toxicology and Chemistry, 1999
AbstractThe polycyclic aromatic hydrocarbon 7-isopropyl−1-methylphenanthrene (retene) induces mixed function oxygenase (MFO) activity of fish. Bile levels of retene and its metabolite(s) were measured in relation to exposure time, exposure concentration, and induction of MFO activity.
Nuno M, Fragoso, Peter V, Hodson, Igor S, Kozin, R Stephen, Brown, Joanne L, Parrott   +4 more
openaire   +2 more sources

Effect of benznidazole on the mixed function oxygenase system from rat liver microsomes.

Archives internationales de pharmacodynamie et de therapie, 1985
Previous Benznidazole (Bz) administration to rats (30 mg/kg, i.p.) significantly prolongs their pentobarbital sleeping time. This prolonging effect of Bz administration correlates with the inhibitory action of Bz on the liver aminopyrine or ethylmorphine N-demethylase activities. Inhibition of these enzyme systems by Bz is non-competitive and would not
M, Masana, E G, de Toranzo, M, Rubio, J A, Castro   +3 more
openaire   +1 more source