Results 171 to 180 of about 6,637 (223)
Biochemical Pharmacology, 1977 Abstract Treatment of pregnant rats with 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD) resulted in a dose-dependent induction of a mixed-function oxidase system in fetal and maternal extra-hepatic tissues. At doses of 6 μmg/kg, aryl hydrocarbon hydroxylase (AHH) activity was increased 24-, 22- and 4-fold in fetal lung, kidney and skin, respectively ...
David L Berry, K Zachariah, M J Namkung
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Journal of Ethnopharmacology, 1997 The present study reports on the effects of horminone on serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, on hepatic cytochrome P450 (P450) and cytochrome b5 (cyt b5) contents and on the activities of NADPH-cytochrome P450 reductase (NR), mixed function mono-oxygenases (MFO), glutathione-S-transferase (GST) and ...
Rui Ferreira, Fatima Candeias
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Journal of Urology, 1982 The responsiveness of BCNU treated mice to phenobarbital (Pb) induction of hepatic microsomal mixed function oxygenase (MFO) activity was studied. BCNU (30 mg/kg ip) produced significant (P less than 0.05) decreases in cytochrome P-450, total ethylmorphine metabolism (TEM) and ethylmorphine N-demethylase (EMN) by 21 days after treatment.
V L, Wilson, R E, Larson
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Use of mixed-function oxygenases to monitor contaminant exposure in wildlife
Environmental Toxicology and Chemistry, 1989Abstract This overview examines the utility of mixed-function oxygenase (MFO) enzymes as a bio-effects monitor for wildlife (amphibians, reptiles, birds and mammals) in view of their widespread use as indicators of contaminant exposure in aquatic invertebrates and fish.
David J Hoffman
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The influence of pregnenolone-16α-carbonitrile on hepatic mixed-function oxygenases
Steroids, 1971Summary 3β-hydroxy-20-oxo-5-pregnene-16α-carbonitrile [Pregnenolone-16α-carbonitrile (PCN)] unlike the naturally-occurring steroid pregnenolone, enhances the plasma clearance of pentobarbital, and elicits a corresponding increase in the production of 14C-pentobarbital metabolites as well as in liver weight, microsomal protein concentration, NADPH ...
B Solymoss
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Annual Review of Physiology, 1983
The microsomal steroidogenic enzymes catalyze reactions important in determining both the quantity and the identity of glandular secretory prod ucts. By determining cell function, changes in the rates of these reactions can effect differentiation. The recognition of these control points in steroid hormone biosynthesis lagged because major research ...
H Richard Fevold
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The microsomal steroidogenic enzymes catalyze reactions important in determining both the quantity and the identity of glandular secretory prod ucts. By determining cell function, changes in the rates of these reactions can effect differentiation. The recognition of these control points in steroid hormone biosynthesis lagged because major research ...
H Richard Fevold
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Journal of the Fisheries Research Board of Canada, 1978 Levels of hepatic cytochrome P-450 and the catalytic functions benzo[a]pyrene hydroxylase and aminopyrine demethylase were significantly greater in populations of mummichog, Fundulus heteroclitus, sampled from contaminated marshes than in those fish ...
John J Stegeman
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Comparison of liver mixed-function oxygenase and antioxidant enzymes in vertebrates
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2004We performed a comparative analysis of cytochrome P450, cytochrome b5, MFO associated enzymes and cytosolic antioxidant enzymes in hepatic microsomes and cytosolic fractions prepared from five animal species representing three vertebrate classes living in tropical conditions (Brazil).
Thomaz A A, Rocha-e-Silva +5 more
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Review and perspective on the use of mixed-function oxygenase enzymes in biological monitoring
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1987It is often suggested that changes in simple biochemical/physiological responses may be useful for predicting the impacts of pollutants at population and community levels of biological organization. There are serious conceptual constraints to such a thesis and its seems likely that such simple responses can go no further than serving as early warning ...
J F, Payne +3 more
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