Results 191 to 200 of about 6,637 (223)
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Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1981
Abstract 1. 1. Selenium- and vitamin E-depleted chicks were fed diets containing 0 or 0.2 ppm supplemental Se and/or 0 or 100 IU/kg vitamin E for 12 days; phenobarbital or water was administered orally for the final 6 days. 2. 2. Hepatic microsomal MFO activities, cytochrome P 450 levels and NADPH-cytochrome c reductase activities were not
S M, Pilch, G F, Combs
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Abstract 1. 1. Selenium- and vitamin E-depleted chicks were fed diets containing 0 or 0.2 ppm supplemental Se and/or 0 or 100 IU/kg vitamin E for 12 days; phenobarbital or water was administered orally for the final 6 days. 2. 2. Hepatic microsomal MFO activities, cytochrome P 450 levels and NADPH-cytochrome c reductase activities were not
S M, Pilch, G F, Combs
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Experimental and Molecular Pathology, 1982
Abstract The relation between incorporation of 14C from 14CCl4 into liver lipids and damage to the mixed functional oxygenase system of liver microsomes was investigated in rats of different sex or differently pretreated. Under the respective conditions of pretreatment the 14C incorporation rate and the relative decrease of the cytochrome P-450 level
U, Fander, W, Haas, H, Kröner
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Abstract The relation between incorporation of 14C from 14CCl4 into liver lipids and damage to the mixed functional oxygenase system of liver microsomes was investigated in rats of different sex or differently pretreated. Under the respective conditions of pretreatment the 14C incorporation rate and the relative decrease of the cytochrome P-450 level
U, Fander, W, Haas, H, Kröner
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A bleached-kraft mill effluent fraction causing induction of a fish mixed-function oxygenase enzyme
Environmental Toxicology and Chemistry, 1996Abstract Pulp mill effluents contain a myriad of chemicals that have the potential to cause deleterious effects on aquatic biota in receiving waters. Some of these chemicals evoke an acute lethal response of exposed biota while others evoke sublethal responses.
B. Kent Burnison +3 more
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Biochemical and Biophysical Research Communications, 1974
Microsome-mediated metabolic activation of aflatoxin B1 (AFB1) and benzo[a]-pyrene (BP), as determined by the in vitro formation of DNA binding metabolites, was studied, using hepatic microsomes from untreated, phenobarbital (PB)-treated and 3-methylcholanthrene (MC)-treated male rats.
H L, Gurtoo, N, Bejba
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Microsome-mediated metabolic activation of aflatoxin B1 (AFB1) and benzo[a]-pyrene (BP), as determined by the in vitro formation of DNA binding metabolites, was studied, using hepatic microsomes from untreated, phenobarbital (PB)-treated and 3-methylcholanthrene (MC)-treated male rats.
H L, Gurtoo, N, Bejba
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Cancer Chemotherapy and Pharmacology, 1985
At a high dose, cyclophosphamide (Cy, 200 mg/kg) causes depression of the enzyme activity of the hepatic mixed function oxygenase (MFO) system in Sprague-Dawley rats. The present report provides evidence for the early regeneration of the depleted enzyme activity in Cy-treated rats by purified protein A (P) of Staphylococcus aureus.
M, Dohadwala, P K, Ray
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At a high dose, cyclophosphamide (Cy, 200 mg/kg) causes depression of the enzyme activity of the hepatic mixed function oxygenase (MFO) system in Sprague-Dawley rats. The present report provides evidence for the early regeneration of the depleted enzyme activity in Cy-treated rats by purified protein A (P) of Staphylococcus aureus.
M, Dohadwala, P K, Ray
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Sex differences in cytochrome P-450 and mixed-function oxygenase activity in gonadally mature trout
Biochemical Pharmacology, 1980Abstract Levels of microsomal cytochrome P-450 and aminopyrine demethylase activity in liver and of cytochrome P-450 in kidney of gonadally mature rainbow and brook trout were markedly greater in males than in females. Similar differences appeared in hepatic microsomal NADH- but not in NADPH-cytochrome c reductase activity or cytochrome b 5 ...
J J, Stegeman, M, Chevion
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Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1991
1. 3,3',4,4'-tetrachlorobiphenyl (PCB 77), but not hexachlorobenzene, induced liver microsomal cytochrome P-450 (Cyt P-450), ethoxycoumarin-O-deethylase (ECOD) and ethoxyresorufin-O-deethylase (EROD) in rainbow trout. Maximum induction was observed in a PCB 77 injected group of fish (1.0 mg/kg, i.p.
Tyle, Henrik +2 more
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1. 3,3',4,4'-tetrachlorobiphenyl (PCB 77), but not hexachlorobenzene, induced liver microsomal cytochrome P-450 (Cyt P-450), ethoxycoumarin-O-deethylase (ECOD) and ethoxyresorufin-O-deethylase (EROD) in rainbow trout. Maximum induction was observed in a PCB 77 injected group of fish (1.0 mg/kg, i.p.
Tyle, Henrik +2 more
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Journal of Toxicology and Environmental Health, 1996
A bioassay protocol was optimized for measuring the potency of effluents or waterborne chemicals for inducing mixed-function oxygenase (MFO) activity of rainbow trout (Oncorhynchus mykiss). Measurements of ethoxyresorufin O-deethylase (EROD) can be made with an established endpoint assay using large volumes of reagents and tissue.
P V, Hodson +5 more
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A bioassay protocol was optimized for measuring the potency of effluents or waterborne chemicals for inducing mixed-function oxygenase (MFO) activity of rainbow trout (Oncorhynchus mykiss). Measurements of ethoxyresorufin O-deethylase (EROD) can be made with an established endpoint assay using large volumes of reagents and tissue.
P V, Hodson +5 more
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Effect of benznidazole on the mixed function oxygenase system from rat liver microsomes.
Archives internationales de pharmacodynamie et de therapie, 1985Previous Benznidazole (Bz) administration to rats (30 mg/kg, i.p.) significantly prolongs their pentobarbital sleeping time. This prolonging effect of Bz administration correlates with the inhibitory action of Bz on the liver aminopyrine or ethylmorphine N-demethylase activities. Inhibition of these enzyme systems by Bz is non-competitive and would not
M, Masana +3 more
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