Results 51 to 60 of about 6,973,250 (229)

Protein engineering of oxygenases for biocatalysis

, 2002
Oxygenase enzymes have seen limited practical applications because of their complexity, poor stabilities, and often low catalytic rates. However, their ability to perform difficult chemistry with high selectivity and specificity has kept oxygenases at ...
Cirino, Patrick C., Arnold, Frances H.
core  

Expanding chemical biology of 2-oxoglutarate oxygenases.

, 2008
Beyond established roles in collagen biosynthesis, hypoxic signaling and fatty acid metabolism, recent reports have now revealed roles for human 2-oxoglutarate-dependent oxygenases in histone and nucleic acid demethylation and in signaling protein ...
Loenarz, C, Christoph Loenarz, Schofield, CJ, Loenarz, Christoph, Schofield, Christopher, Christopher J Schofield   +5 more
core   +1 more source

Mixed oligopoly, public firm behavior, and free private entry [PDF]

, 2012
© 2012 Elsevier B.V. All rights reservedWe analyze a mixed oligopoly with free entry by private firms, assuming that a public firm maximizes an increasing function of output, subject to a break-even constraint.
John Bennett, Bennett, John, La Manna, M, Bennett, J, Manfredi La Manna, La Manna, Manfredi M A   +5 more
core   +1 more source

Optimal Manipulation Rules in a Mixed Duopoly [PDF]

We study the optimal manipulation rules of a public firm’s objective function in a mixed duopoly with imperfect product substitutability. We compare the solutions under quantity and price competition, and the way in which they are affected by the degree of
Corrado Benassi, Marcella Scrimitore, Alessandra Chirco   +2 more
core  

Comparing Gaze-Supported Modalities with Empathic Mixed Reality Interfaces in Remote Collaboration

, 2022
In this paper, we share real-time collaborative gaze behaviours, hand pointing, gesturing, and heart rate visualisations between remote collaborators using a live 360 ° panoramic-video based Mixed Reality (MR) system.
Billinghurst, M., Lee, G.A., Jing, A., Gupta, K., McDade, J.   +4 more
core   +1 more source

Functional and inhibition studies on 2-oxoglutarate-dependent oxygenases

, 2012
This thesis explores roles of 2-oxoglutarate-dependent (2OG) oxygenases as interfaces that modulate steps in the flow of genetic information in cells in response to oxygen availability.
Thalhammer, Armin
core   +1 more source

An all‐in‐one fucosylated gold nanocluster probe enables NIR‐II imaging and multi‐mechanistic therapy of acute kidney injury

BMEMat, EarlyView.
This study developed a fucoside‐targeted gold nanocluster probe that enables early NIR‐II imaging and multi‐mechanistic therapy for acute kidney injury, effectively mitigating oxidative stress, modulating inflammatory responses, and inhibiting ferroptosis to improve renal outcomes. Abstract Acute kidney injury (AKI) remains a life‐threatening condition
Ping Zhang, Boning Tan, Suqing Feng, Beibei Gu, Ting Feng, Haiguang Zhu, Jianping Xie, Xun Yuan   +7 more
wiley   +1 more source

Mechanism of Isonitrilase, a Nonheme Iron Decarboxylase Involved in the Biosynthesis of the Isonitrile Group in Peptides: A Computational Study

Chemistry – A European Journal, EarlyView.
A combination of molecular dynamics and quantum mechanics calculations shows that substrate is tightly bound inside the enzyme structure that enables two successive catalytic cycles with dioxygen and α‐ketoglutarate with an initial desaturation followed by hydrogen abstraction and decarboxylation steps to form an isonitrile substituent.
Chengxu Zhu, Sam P. de Visser
wiley   +1 more source

Immersive mixed-reality configuration of hybrid user interfaces

, 2005
Information in hybrid user interfaces can be spread over a variety of different, but complementary, displays, with which users interact through a potentially equally varied range of interaction devices. Since the exact configuration of these displays and
A. Olwal, Feiner, S., Olwal, Alex,, Sandor, C., S. Feiner, Bell, B., Olwal, A., B. Bell, C. Sandor   +8 more
core   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source