Results 41 to 50 of about 6,973,250 (229)

A note on bimodality in the log-likelihood function for penalized spline mixed models

, 2009
For a smoothing spline or general penalized spline model, the smoothing parameter can be estimated using residual maximum likelihood (REML) methods by expressing the spline in the form of a mixed model.
Welham, S. J., Thompson, R.
core   +1 more source

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

Advanced Science, EarlyView.
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He   +6 more
wiley   +1 more source

2-oxoglutarate-dependent oxygenases

, 2018
2-Oxoglutarate (2OG)-dependent oxygenases (2OGXs) catalyze a remarkably diverse range of oxidative reactions. In animals, these comprise hydroxylations and N-demethylations proceeding via hydroxylation; in plants and microbes, they catalyze a wider range
Leissing, TM, Thomas M. Leissing, Chowdhury, R, Richard J. Hopkinson, Rasheduzzaman Chowdhury, Md. Saiful Islam, Islam, MS, Leissing, Thomas, Islam, Md. Saiful, Schofield, CJ, Hopkinson, RJ, Schofield, Christopher, Christopher J. Schofield   +12 more
core   +1 more source

Dual Repression by IPA1 Fine‐Tunes OsbZIP79‐Mediated Salt Tolerance in Rice

Advanced Science, EarlyView.
Dual repression by IPA1 fine‐tunes OsbZIP79‐mediated salt tolerance in rice: direct transcriptional inhibition under normal conditions and salt‐induced degradation under stress. This dual mechanism activates OsbZIP79 to regulate Na+/K+ homeostasis and redox balance via downstream genes, enabling optimal salt stress response.
Hui Wang, Bo Liu, Can Hu, Chenfan Zheng, Yuting Wei, Xier Xu, Wei Yang, Yu Fang, Guangle Shen, Pedro García‐Caparros, Conghe Zhang, Qingyao Shu, Meng Jiang   +12 more
wiley   +1 more source

A photoreactive small-molecule probe for 2-oxoglutarate oxygenases. [PDF]

, 2011
2-oxoglutarate (2-OG)-dependent oxygenases have diverse roles in human biology. The inhibition of several 2-OG oxygenases is being targeted for therapeutic intervention, including for cancer, anemia, and ischemic diseases.
Ya Min Tian, Mackeen, MM, Ratcliffe, Peter J., Ivanhoe K.H. Leung, Ratcliffe, Peter, Fischer, Roman, Kessler, BM, Dante Rotili, Antonello Mai, Fischer, R, Mikael Altun, Leung, Ivanhoe K.H., Alexander Wolf, Rotili, D, Wolf, A, Mai, A, Altun, M, Akane Kawamura, Benedikt m Kessler, Kawamura, Akane, Roman Fischer, Leung, IK, I. k. Leung, Ya-min Tian, Mukram M. Mackeen, Christopher J. Schofield, Christopher j Schofield, Altun, Mikael, Wolf, Alexander, Mackeen, Mukram M., Peter J. Ratcliffe, Kessler, Benedikt M., Tian, YM, ROTILI, Dante, Tian, Ya-min, Schofield, Christopher J., MAI, Antonello, Benedikt M. Kessler, Schofield, Christopher, Mukram m Mackeen, Peter j Ratcliffe   +40 more
core   +1 more source

Neuroprotection after transient middle cerebral artery occlusion in male rats using kojic acid nanostructured lipid carriers: A behavioral, biochemical, and histological study on hippocampal CA1 region

Animal Models and Experimental Medicine, EarlyView.
This study demonstrates that kojic acid–loaded nanostructured lipid carriers (KA‐NLC) provide significant neuroprotection in a male rat model of middle cerebral artery occlusion (MCAO)–induced stroke. Treatment with KA‐NLCs reduced cerebral edema, improved motor and coordination balance and neurological scores, and enhanced spatial and avoidance memory.
Mobina Gheibi, Erfan Ghadirzadeh, Javid Tebyani, Seyedeh Mohadeseh Moyaedi, Khadijeh Khezri, Majid Saeedi, Ali Siahposht‐Khachaki, Narges Karimi, Melika Pourhossein, Shiva Shadi, Sasan Shafiei, Atena Sharifi‐Razavi   +11 more
wiley   +1 more source

A calibration function from change points using linear mixed models [PDF]

, 2019
The change point problem is an interesting topic in both cross-sectional and longitudinal settings. In the cross-sectional scenario, the change point problem has been studied extensively.
Garcia Cruz, Ehidy Karime
core  

Adenosine monophosphate–activated protein kinase activation is associated with suppression of NLRP3 inflammasome–mediated neuroinflammation in a weight‐drop model of traumatic brain injury in Sprague–Dawley rats

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the study's schematic model. Adenosine monophosphate–activated protein kinase (AMPK) activators exhibited neuroprotection in the weight‐drop model of traumatic brain injury by improving cognition and regulating oxidative stress, microglial activation, and nucleotide‐binding oligomerization domain, leucine‐rich repeat,
Triveni Kodi, Paka Sravan Kumar, Krishnadas Nandakumar, Anoop Kishore   +3 more
wiley   +1 more source

Functional and evolutionary relationships among diverse oxygenases.

, 1992
Oxygenases that incorporate one or two atoms of dioxygen into substrates are found in many metabolic pathways. In this article, representative oxygenases, principally those found in bacterial pathways for the degradation of hydrocarbons, are reviewed ...
Kok M, Harayama S, Neidle EL
core   +1 more source

Endogenous timing in a mixed duopoly [PDF]

, 2007
This paper addresses the issue of endogenizing the equilibrium solution when a private - domestic or foreign - firm competes in the quantities with a public, welfare maximizing firm.
De Feo, Giuseppe, Amir, Rabah
core   +5 more sources