Results 21 to 30 of about 11,772 (251)

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Discovery and characterization of a new family of lytic polysaccharide monooxygenases [PDF]

, 2014
Lytic polysaccharide monooxygenases (LPMOs) are a recently discovered class of enzymes capable of oxidizing recalcitrant polysaccharides. They are attracting considerable attention owing to their potential use in biomass conversion, notably in the ...
A Levasseur, AB Boraston, Bernard Henrissat, BL Cantarel, CM Phillips, DE Wilcox, E Krissinel, FL Aachmann, G Langer, G Vaaje-Kolstad, Gideon J Davies, Glyn R Hemsworth, GM Sheldrick, GN Murshudov, GR Hemsworth, GR Hemsworth, HJ Gilbert, I Gelfand, IW Davis, J Peisach, J-F Flot, M Bey, M Iwaizumi, M Wu, MD Winn, P Emsley, P Gouet, Paul H Walton, PV Harris, R Kittl, RC Edgar, RJ Quinlan, S Karkehabadi, SJ Horn, TN Petersen, W Kabsch, WT Beeson, X Li, Z Forsberg   +38 more
core   +2 more sources

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Safety of Prescription Nonsteroidal Anti‐inflammatory Drugs in Adults With Inflammatory Bowel Disease: Data From a Large Administrative Claims Cohort

Arthritis Care &Research, EarlyView.
Objective The concern that nonsteroidal anti‐inflammatory drugs (NSAIDs) may precipitate flares of inflammatory bowel disease (IBD) has limited their use in managing musculoskeletal symptoms in those with IBD, but safety data are mixed. Methods This retrospective cohort study included patients with IBD aged at least 18 years from Optum's deidentified ...
Adam S. Mayer, Rui Xiao, Meenakshi Bewtra, Michael D. George, Pamela F. Weiss   +4 more
wiley   +1 more source

Structure and boosting activity of a starch-degrading lytic polysaccharide monooxygenase. [PDF]

, 2015
Lytic polysaccharide monooxygenases (LPMOs) are recently discovered enzymes that oxidatively deconstruct polysaccharides. LPMOs are fundamental in the effective utilization of these substrates by bacteria and fungi; moreover, the enzymes have significant
Davies, Gideon J, De Maria, Leonardo, Dupree, Paul, Frandsen, Kristian EH, Harris, Paul V, Hemsworth, Glyn R, Henrissat, Bernard, Johansen, Katja S, Lenfant, Nicolas, Lo Leggio, Leila, Poulsen, Jens-Christian N, Simmons, Thomas J, Soong, Chee-Leong, Stringer, Mary A, Tovborg, Morten, Tryfona, Theodora, von Freiesleben, Pernille, Walton, Paul H   +17 more
core   +9 more sources

An Engineered Living Material With Pro‐Angiogenic Activity Inducible by Near‐Infrared Light

Advanced Functional Materials, EarlyView.
NIR‐responsive engineered living materials (ELMs) for controlled angiogenesis: Near‐infrared (800 nm) light activates engineered probiotic bacteria within alginate‐based living materials to secrete a blood vessel‐regenerating protein. The released protein promotes pro‐angiogenic effects in endothelial networks and chick chorioallantoic membranes.
Anwesha Chatterjee, Stefanie S. M. Meier, Sara Trujillo, Andreas Möglich, Shrikrishnan Sankaran   +4 more
wiley   +1 more source

Genome-Wide Association Study and Pathway-Level Analysis of Kernel Color in Maize. [PDF]

, 2019
Rapid development and adoption of biofortified, provitamin A-dense orange maize (Zea mays L.) varieties could be facilitated by a greater understanding of the natural variation underlying kernel color, including as it relates to carotenoid biosynthesis ...
Diepenbrock, Christine H, Gore, Michael A, Mateos-Hernandez, Maria, Mathew, Deepu, Owens, Brenda F, Rocheford, Torbert, Tiede, Tyler, Wu, Di   +7 more
core   +2 more sources

Designed Liquid Crystalline Nanoassemblies From Clinically Validated Polyunsaturated Lipids for Combined Antioxidant, Anti‐Apoptotic, and Neurotrophic Treatments

Advanced Healthcare Materials, EarlyView.
Ionizable lipid nanoparticles target multiple pathological pathways in neurodegeneration. The designed self‐assembled materials undergo a pH‐triggered structural transformation from a cubosome/hexosome coexistence to a hexosome phase, enhancing intracellular delivery of a multi‐target phytochemical formulation. The antioxidant‐loaded pH‐responsive LNPs
Thelma Akanchise, Fucen Luo, Borislav Angelov, Yuru Deng, Angelina Angelova   +4 more
wiley   +1 more source

Clinical phenotype and genetic mutation of fatty acid hydroxylase - associated neurodegeneration: analysis of four cases

Chinese Journal of Contemporary Neurology and Neurosurgery, 2017
Objective To report 4 cases of fatty acid hydroxylase - associated neurodegeneration (FAHN) and to summarize the clinical and genetic characteristics of FAHN by literatures review.
Xiao-jun HUANG, Xiao-li LIU, Tian WANG, Jun-yi SHEN, Sheng-di CHEN, Wei-guo TANG, Li CAO   +6 more
doaj  

Iron conservation by reduction of metalloenzyme inventories in the marine diazotroph Crocosphaera watsonii [PDF]

, 2010
The marine nitrogen fixing microorganisms (diazotrophs) are a major source of nitrogen to open ocean ecosystems and are predicted to be limited by iron in most marine environments.
Bertrand, Erin M., Bulygin, Vladimir V., Dutkiewicz, Stephanie, Follows, Michael J., Monteiro, Fanny Meline, Moran, Dawn M., Saito, Mak A., Valois, Frederica W., Waterbury, John B.   +8 more
core   +2 more sources