Results 71 to 80 of about 259,405 (306)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Discrete Mathematics, 2012 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Dourado, Mitre C. +4 more
openaire +2 more sources
Approximation algorithms for orienting mixed graphs [PDF]
Theoretical Computer Science, 2011 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Elberfeld, Michael +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
On Mixed Metric Dimension of Some Path Related Graphs
IEEE Access, 2020 A vertex $k\in V_{G}$ determined two elements (vertices or edges) $\ell,m \in V_{G}\cup E_{G}$ , if $d_{G}(k,\ell)\neq d_{G}(k,m)$ . A set $R_ {\text {m}}$ of vertices in a graph $G$ is a mixed metric generator for $G$ , if two distinct elements
Hassan Raza, Ying Ji, Shaojian Qu
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Electronic Notes in Discrete Mathematics, 2014 Cayley graphs are well known objects with interesting properties, also in the context of Moore graphs and digraphs. In $1978$ Bos\'ak extended Moore's property to the mixed setting (with arcs allowed along with edges), in the so called mixed Moore graphs: those having a unique trail--path?
López Lorenzo, Ignacio +2 more
openaire +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
A Graph Theoretic Perspective on CPM(Rel) [PDF]
Electronic Proceedings in Theoretical Computer Science, 2015 Mixed states are of interest in quantum mechanics for modelling partial information. More recently categorical approaches to linguistics have also exploited the idea of mixed states to describe ambiguity and hyponym / hypernym relationships.
Daniel Marsden
doaj +1 more source
Improved Approximation for Orienting Mixed Graphs [PDF]
Algorithmica, 2012 An instance of the maximum mixed graph orientation problem consists of a mixed graph and a collection of source-target vertex pairs. The objective is to orient the undirected edges of the graph so as to maximize the number of pairs that admit a directed source-target path.
Gamzu, Iftah, Medina, Moti
openaire +4 more sources