Results 61 to 70 of about 3,434,361 (250)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Mixed allele malaria vaccines: Host protection and within-host selection [PDF]

, 2008
Malaria parasites are frequently polymorphic at the antigenic tat-gets of many candidate vaccines, presumably as a consequence of selection pressure from protective immune responses.
Anders, Robin F., Chan, Brian H.K., Barclay, Victoria C., Chan, Brian H K; id_orcid, Chan, Brian H. K., Read, Andrew F.   +5 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Mixed tuberculosis infections in rural South Vietnam. [PDF]

, 2012
Contains fulltext : 124292.pdf (Publisher’s version ) (Open Access)Tuberculosis patients may be infected with or have disease caused by more than one Mycobacterium tuberculosis strain, usually referred to as "mixed infections." These ...
Lan, Nguyen T. N., van Soolingen, D, Cobelens, F.G., Kremer, Kristin, Dung, N.H., Kremer, K, Huyen, M.N., Dung, Nguyen H., Buu, T.N., Buu, Tran N., Buu, TN, Tiemersma, Edine W., Cobelens, Frank G. J., Kremer, K., Tiemersma, E.W., Huyen, MN, Caws, Maxine, Dung, NH, Soolingen, D. van, Lan, N.T., Caws, M., van Soolingen, Dick, Lan, NT, Huyen, Mai N. T., Cobelens, FG, Caws, M, Tiemersma, EW   +26 more
core   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Application of targeted metagenomic next-generation sequencing in pneumonia patients

Microbiology Spectrum
After the coronavirus disease 2019 (COVID-19) pandemic, the incidence rate of mixed infections, especially in critically ill patients with severe pneumonia, increases due to the immunity gap and has also been proven to be associated with mortality ...
Guanjun Ren, Liyun Ma, Chunliang Yan, Qishan Xue, Huijuan Zhang, Wei Wang, Xiyan Ren, Yun Lei, Shaofei Li, Yafeng Liu, Qingyue Zheng, Shigang Wei, Yue Zhang, Xiao Wang   +13 more
doaj   +1 more source

Fungal-Bacterial Interactions in Health and Disease

Pathogens, 2019
Fungi and bacteria encounter each other in various niches of the human body. There, they interact directly with one another or indirectly via the host response. In both cases, interactions can affect host health and disease.
Wibke Krüger, Sarah Vielreicher, Mario Kapitan, Ilse D. Jacobsen, Maria Joanna Niemiec   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Applied genomics: data mining reveals species-specific malaria diagnostic targets more sensitive than 18S rRNA. [PDF]

, 2011
Accurate and rapid diagnosis of malaria infections is crucial for implementing species-appropriate treatment and saving lives. Molecular diagnostic tools are the most accurate and sensitive method of detecting Plasmodium, differentiating between ...
Jenna Oberstaller, Ganesh Srinivasamoorthy, Venkatachalam Udhayakumar, John W. Barnwell, Leopoldo Villegas, S. Patrick Kachur, Demas, Allison, Kissinger, Jessica C, Villegas, Leopoldo, Abdunoor M. Kabanywanyi, Jessica C. Kissinger, Deborah Sumari, Escalante, Ananias A, Lucchi, Naomi W, Udhayakumar, Venkatachalam, Sumari, Deborah, Peterson, David S, Ananias A. Escalante, Naomi W. Lucchi, Jeremy DeBarry, DeBarry, Jeremy, David S. Peterson, Oberstaller, Jenna, Allison Demas, Srinivasamoorthy, Ganesh, Kachur, S Patrick, Kabanywanyi, Abdunoor M, Barnwell, John W   +27 more
core   +1 more source

Healthcare Associated Infections annual report; Report to the legislature concerning the status of the Healthcare Associated Infections Initiative

, 2008
Annual; Began with Oct. 1, 2008.; Description based on: Oct. 1, 2008; tilte from PDF cover (publisher's web site, viewed May 21, 2009).; At head of title: State of Connecticut.; "An Act Concerning Hospital Acquired Infections."; Latest issue consulted ...
Healthcare Associated Infections Program (Conn.)
core   +1 more source