Results 121 to 130 of about 1,975,816 (285)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

POWERLIB: SAS/IML Software for Computing Power in Multivariate Linear Models

Journal of Statistical Software, 2009
The POWERLIB SAS/IML software provides convenient power calculations for a widerange of multivariate linear models with Gaussian errors. The software includes the Box,Geisser-Greenhouse, Huynh-Feldt, and uncorrected tests in the univariate" approach ...
Jacqueline L. Johnson, Keith E. Muller, James C. Slaughter, Matthew J. Gurka, Matthew J. Gribbin Sano, Sean L. Simpson   +5 more
doaj  

Linear mixed models with endogenous covariates: modeling sequential treatment effects with application to a mobile health study

, 2019
Mobile health is a rapidly developing field in which behavioral treatments are delivered to individuals via wearables or smartphones to facilitate health-related behavior change.
Klasnja, Predrag, Murphy, Susan A., Qian, Tianchen   +2 more
core  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Markov-Switching MIDAS Models [PDF]

This paper introduces a new regression model - Markov-switching mixed data sampling (MS-MIDAS) - that incorporates regime changes in the parameters of the mixed data sampling (MIDAS) models and allows for the use of mixed-frequency data in Markov ...
Massimiliano Marcellino, Pierre Guerin
core  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Formulating and Solving Exhaustible Resource Models as Mixed Complementarity Problems in GAMS [PDF]

In this paper a formulation of dynamic non-linear programs as mixed complementarity problems (mcp) is shown. Models of exhaustible resource markets are used to describe the transformation.
Sven M. Flakowski
core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

The Success-Score in Professional Football: a metric of playing style or a metric of match outcome?

International Journal of Computer Science in Sport
In the growing field of data analysis in soccer tracking data is analyzed utilizing increasingly complex methods to account for the dynamic, multifactorial nature of the game.
Brinkjans David, Paul Yannik, Perl Jürgen, Memmert Daniel   +3 more
doaj   +1 more source

Methodological implementation of mixed linear models in multi-locus genome-wide association studies. [PDF]

Brief Bioinform, 2018
Wen YJ, Zhang H, Ni YL, Huang B, Zhang J, Feng JY, Wang SB, Dunwell JM, Zhang YM, Wu R.   +9 more
europepmc   +1 more source