Results 161 to 170 of about 60,348,366 (292)

Evaluation of the role development and implementation of advanced practice nurses in an Austrian university hospital: a mixed methods research protocol. [PDF]

BMJ Open
Pann KJ, Gruber SE, Eßl-Maurer R, Moser F, Ewers A.   +4 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Factors Affecting Job Satisfaction Among Diagnostic Radiography Technologists in Kuwait: A Mixed-Methods Research Study. [PDF]

Radiol Res Pract
Al-Qattan EM, Al-Hamad H, Khalaf A, Saeed R, Akhtar N.   +4 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Evaluation of School Health Policies and Practices in Brazil and Portugal: Protocol for Mixed Methods Research. [PDF]

JMIR Res Protoc
Freitas BHBM, Neves ET, Melo MC, Sousa MC, Arrué AM, Santos MM, Leal LP, Marcheti MA, Bortolini J, Gaíva MAM, Henriques CMDG, Pires MDCCM, Menino EPDSG.   +12 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Using logic models in mixed methods research: the example of the Integrating English randomised controlled trial

This chapter focuses on using logic models as a way of framing mixed methods approaches, which have come to prominence in randomised controlled trials (RCTs).
Moore, Nick, Culliney, Martin, Coldwell, Mike   +2 more
core  

Mixed-methods research in medical education: Lessons from a meta-study of methodological practice. [PDF]

Med Educ
Cleland J, MacLeod A, van Schalkwyk S, Ellaway RH.   +3 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Management of miscarriage: a matter of choice? A mixed- methods research study in Northern Ireland. [PDF]

Reprod Health
Galeotti M, Mitchell G, Tomlinson M, Aventin Á.   +3 more
europepmc   +1 more source