Results 141 to 150 of about 2,457,884 (250)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Adolescent literacy, trust, and acceptance of vaccines before and after educational intervention: protocol for a mixed methods research. [PDF]

BMC Public Health
de Freitas BHBM, Lima JC, Sartori AL, Haeffner R, Nemer CRB, da Silva ARV, Sales CMM, Garcia EM, Bortolini J, Ratzan SC.   +9 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Challenges of ICT use for nurse-patient communication in Portugal: a mixed methods research. [PDF]

BMC Health Serv Res
Peres M, Simões de Almeida R, Moreira A.   +2 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

ENding HIV transmission to infants by Generating Evidence to optimise prevention and care for pregnant and postpartum Adolescent Girls and young women with HIV in Tanzania (ENGAGE): study protocol for a mixed-methods research project. [PDF]

BMJ Open
Lyatuu GW, Larsson EC, Siril H, Mbunda T, Urrio RF, Machumi L, Machang'u D, Unkels R, Mauka WI, Mahande MJ, Simba B, Festo C, Mganga A, Mfaume RS, Laizer S, Rutatinisibwa H, Kibao A, Muhode P, Njau P, Maokola W, Rwebembera A, Msangi M, Nyamhagatta MA, Sunguya BF, Naburi H, Ekström AM, Kågesten AE.   +26 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A Call for the Inclusion of Mixed Methods Research in the Undergraduate Psychology Curriculum

Frontiers in Psychology, 2019
Lynne D. Roberts, Peter J. Allen
doaj   +1 more source

Development of a minimum data set for a pediatric and neonatal Medication Administration Clinical Decision Support System (MACDSS), mapped to FHIR: a mixed-methods research synthesis. [PDF]

BMC Med Inform Decis Mak
Norouzi S, Agah J, Sarkohi Z, Ahmadian L.   +3 more
europepmc   +1 more source