Results 131 to 140 of about 60,348,366 (292)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Future Challenges for Mixed Methods Research in Nursing and the Health Sciences
, 2009 Nursing and health science researchers have, increasingly, embraced mixed methods to guide their exploration of the complex phenomena that infl uence human health. The mixed methods approach offers a fl exibility and depth of insight that is not possible
Andrew, Sharon +5 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
A mixed methods public participation GIS (PPGIS) in tourism : a concurrent triangulation approach
This chapter discusses mixed methods Public Participation Geographic Information Systems (PPGIS) in tourism. It provides the rationale for using mixed methods PPGIS in tourism and discusses the context where it was used. The context was a study exploring
Waleghwa, Beatrice,
core +1 more source
Determining a voice to use in writing about mixed methods research
, 2011 Education researchers conducting mixed methods research in cross-cultural contexts can be confronted with a number of binaries through which they need to weave their way.
Dovona-Ope, Dinah R.
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Che genere di partecipazione? Indagine mix methods sui giovani napoletani di oggi
, 2018 Il progressivo allontanamento dei giovani dalla politica è testimoniato dalla loro difficoltà di partecipare socialmente e politicamente secondo canali standardizzati.
salvatore monaco, cristiano felaco
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Mixed Methods Research as Third Methodological Movement:
جامعه شناسی کاربردی, 2010 Mixed Method Research is considered as the latest methodological orientation in social and behavioralsciences and sociology which has been developed following a long period of intra-paradigm controversiesbetween quantitative and qualitative approaches ...
Ahmad Mohammadpour +2 more
doaj