Results 121 to 130 of about 2,640,675 (296)

Integrating the temporal dimension in longitudinal mixed methods research: key methodological considerations for design and implementation

Huli yanjiu
Drawing on recent international literature and representative case studies,this paper systematically summarized and interpreted the design logic,key implementation principles,data integration techniques,and common challenges of longitudinal mixed methods
LIU Ning, YAN Bixuan, GAO Jie, LI Fengwei, JI Ying, CHU Hongling   +5 more
doaj  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

College students' justification for digital piracy: a mixed methods study

, 2012
Click on the DOI link to access the article (may not be free).A mixed methods project was devoted to understanding college students' justification for digital piracy.
Yu, Sz De
core   +1 more source

Mixed Methods or Mixed Meanings in Research? [PDF]

Nursing Science Quarterly, 2009
openaire   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Mixed Methods

, 2012
This presentation provides and overview of mixed methods as a methodology in the social sciences. Crucially the slides are concerned with issues of research design - not analysis. The presentation ends with some seminar questions to encourage students to
Dr Luke Sloan
core  

Future Challenges for Mixed Methods Research in Nursing and the Health Sciences

, 2009
Nursing and health science researchers have, increasingly, embraced mixed methods to guide their exploration of the complex phenomena that infl uence human health. The mixed methods approach offers a fl exibility and depth of insight that is not possible
Andrew, Sharon, Andrew, Sharon (R11224), Sharon Andrew, Elizabeth J. Halcomb, Halcomb, Elizabeth (R9671), Halcomb, EJ   +5 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Identifying stakeholder preferences for communicating impact from medical research: a mixed methods study [PDF]

Background Documentation of research outcomes using impact case studies (ICS) is increasingly required to demonstrate the wider societal benefits of research.
Viney, I., Samarasinghe, B., Pringle, A., Pitrolino, K.   +3 more
core   +1 more source