Results 151 to 160 of about 60,348,366 (292)

Immunobiological cold chain performance assessment in Brazil: mixed methods research. [PDF]

BMC Health Serv Res
Amaral GG, Pinto IC, de Andrade TIX, Silva BS, Guimarães EAA, de Oliveira VC.   +5 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Pragmatism and Methodology

Designed for social scientists working with big data sets, this book maps out the cycle of research, from epistemology and ethical questions to data collection and analysis.
Gillespie, Alex, Glăveanu, Vlad, de Saint Laurent, Constance   +2 more
core   +1 more source

Avoiding Fragmentation and Salami Slicing in Mixed Methods Research. [PDF]

Clin Nurs Res
Nijkamp N, Calleja P, Jack L, Sahay A.
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Mixed Methods Research Approach: An Overview

Проблеми на постмодерността
Mixed methods research involves using both quantitative and qualitative methodologies in a single study or inquiry to gain a more comprehensive understanding of the issue under investigation.
Josephine Oranga, Audrey Matere, Evelyn Njurai   +2 more
doaj  

Using Mixed-Methods Research to Address Stagnant Operative Mortality Rates in Congenital Heart Surgery. [PDF]

Crit Care Explor
Venna A, Haverty MC, Almarkhan A, Fetch A, Kreutzer J, Hom LA, Wessel DL, Harahsheh AS, Domnina Y, d'Udekem Y.   +9 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Seeking HELP beyond the pill: Women's perceptions of informed consent for medication abortion: Mixed methods research. [PDF]

PLoS One
Tsulukidze M, Di Cicco G, Longbons Cox T, Rafferty KA, Grande SW, Skop I, Collison D.   +6 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source