Results 171 to 180 of about 5,584,216 (285)

Patient journey and Quality of Life for Patients with Idiopathic Pulmonary Fibrosis (IPFLife) in China: a sequential exploratory mixed methods research protocol. [PDF]

BMJ Open
Chu H, Ding Y, Zhou Y, Ji P, Yuan B, Zhan X, Lu X, Liu N, Zhang Y, Yan B, Fang X, Xu X, Huang Z, Li W, Shen N, Zhan S.   +15 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Addressing healthcare needs in an inaugural family medicine clinic in a core city in Japan: Mixed-methods research. [PDF]

J Gen Fam Med
Mizumoto J, Nishimura M, Ishikawa N, Hisatake K, Satake E, Yamamoto S, Tsuno S.   +6 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Exploring Co-production as an Implementation Strategy for Trauma-Informed Care in a Youth-Focused HIV Clinic in Memphis, Tennessee: Mixed Methods Research. [PDF]

JMIR Form Res
Brown LL, Wilkins ML, McLean RKD, Stewart JL, Patel ND, Acuña AJ, Audet CM, Sales JM, Pettit AC, Pichon LC.   +9 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

"They Just Don't Want to Feel Forgotten": A Mixed-Methods Research on Patient Satisfaction With Wait Times in Emergency Departments. [PDF]

J Patient Exp
Manukumar AG, Mariathas HH, Patey C, Anaraki NR, Walsh A, Hurley O, Senior D, Etchegary H, Norman P, Asghari S.   +9 more
europepmc   +1 more source

The thorny issue of pluralism, 'paradigm wars' and politics in qualitative methods and mixed methods research [PDF]

, 2014
Bridger, Alexander J.
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

"You do it to cover your own back": The assessment of cervical spine radiculopathy among physiotherapists in the United Kingdom: A mixed methods research study. [PDF]

PLoS One
Mansfield M, Jong ST, Smith T.
europepmc   +1 more source