Results 51 to 60 of about 247,387 (224)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Metric considerations concerning the mixed Littlewood Conjecture [PDF]
, 2009 The main goal of this note is to develop a metrical theory of Diophantine approximation within the framework of the de Mathan-Teulie Conjecture, also known as the `Mixed Littlewood Conjecture'. Let p be a prime.
Bugeaud, Yann +2 more
core +1 more source
Some mixed Hodge structure on l^2-cohomology of covering of K\"ahler manifolds
, 2013 We give methods to compute l^2-cohomology groups of a covering manifolds obtained by removing pullback of a (normal crossing) divisor to a covering of a compact K\"ahler manifold.
CP Rourke +11 more
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Computing dominant metric dimensions of certain connected networks
HeliyonIn the studies of the connected networks, metric dimension being a distance-based parameter got much more attention of the researches due to its wide range of applications in different areas of chemistry and computer science. At present its various types
Imtiaz Ali, Muhammad Javaid, Yilun Shang
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Information metric and Euclidean Janus correspondence
, 2016 We consider the quantum information metric of a family of CFTs perturbed by an exactly marginal operator, which has the dual description of the Euclidean Janus geometries.
Bak, Dongsu
core +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
, 2013 With a basic knowledge of cohomology theory, the background necessary to understand Hodge theory and polarization, Deligne's Mixed Hodge Structure on cohomology of complex algebraic varieties is described.Comment: pages ...
Elzein, Fouad, Trang, Lê Dung
core +3 more sources