Results 61 to 70 of about 249,139 (224)

Sparse metric learning via smooth optimization [PDF]

, 2012
Copyright © 2009 NIPS Foundation23rd Annual Conference on Advances in Neural Information Processing Systems (NIPS 2009), Vancouver, Canada, 7-10 December 2009In this paper we study the problem of learning a low-rank (sparse) distance matrix. We propose a
Campbell, Colin, Huang, Kaizhu, Ying, Yiming   +2 more
core   +2 more sources

Geometry of Gaussian quantum states

, 2015
We study the Hilbert-Schmidt measure on the manifold of mixed Gaussian states in multi mode continuous variable quantum systems. An analytical expression for the Hilbert-Schmidt volume element is derived. Its corresponding probability measure can be used
Link, Valentin, Strunz, Walter T.
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Bures volume of the set of mixed quantum states

, 2005
We compute the volume of the N^2-1 dimensional set M_N of density matrices of size N with respect to the Bures measure and show that it is equal to that of a N^2-1 dimensional hyper-halfsphere of radius 1/2.
Bhattacharyya A, Boya L J, Braunstein S L, Bures D J C, Byrd M S, Caves C, Cencov N N, Dittmann J, Dittmann J, Dittmann J, Eynard B, Fisher R A, Fubini G, Fuchs C A, Fyodorov Y V, Hall M J W, Hans-J rgen Sommers, Hua L K, Jozsa R, Karol Zyczkowski, Kubo F, Lesniewski A, Liese F, Mehta M L, Morozova E A, Nielsen M A, Ohya M, Ozawa M, Petz D, Slater P B, Slater P B, Slater P B, Sommers H-J, Study E, Tilma T, Uhlmann A, Vedral V, Wootters W K, Zyczkowski K, Zyczkowski K, Zyczkowski K, Zyczkowski K   +41 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, Volume 20, Issue 6, Page 1513-1534, June 2026.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, Volume 20, Issue 6, Page 1612-1625, June 2026.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Heat kernel estimates and their stabilities for symmetric jump processes with general mixed polynomial growths on metric measure spaces

, 2019
In this paper, we consider a symmetric pure jump Markov process $X$ on a general metric measure space that satisfies volume doubling conditions. We study estimates of the transition density $p(t,x,y)$ of $X$ and their stabilities when the jumping kernel ...
Bae, Joohak, Kang, Jaehoon, Kim, Panki, Lee, Jaehun   +3 more
core  

Information metric and Euclidean Janus correspondence

, 2016
We consider the quantum information metric of a family of CFTs perturbed by an exactly marginal operator, which has the dual description of the Euclidean Janus geometries.
Bak, Dongsu
core   +2 more sources