Results 61 to 70 of about 25,129 (234)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Mixed codes produce more discriminable stimulus representations. [PDF]
, 2020 A The noisy channel model. A stimulus x is encoded by encoding function tO(x) of order O. Next, the linear transform β is applied before independent Gaussian-distributed noise with variance σ2 is added to the representation.
W. Jeffrey Johnston (8463480) +2 more
core +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Sparse metric learning via smooth optimization [PDF]
, 2010 In this paper we study the problem of learning a low-rank (sparse) distance matrix. We propose a novel metric learning model which can simultaneously conduct dimension reduction and learn a distance matrix. The sparse representation involves a mixed-norm
Yiming Ying (15294005) +2 more
core
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Sparse metric learning via smooth optimization [PDF]
, 2013 Copyright © 2009 NIPS Foundation23rd Annual Conference on Advances in Neural Information Processing Systems (NIPS 2009), Vancouver, Canada, 7-10 December 2009In this paper we study the problem of learning a low-rank (sparse) distance matrix. We propose a
Campbell, Colin +2 more
core
Fractal and FractionalUsing 48 shale samples from the lower member of the Longmaxi Formation in Well YL, in the Middle Yangtze region, we investigate the fractal characteristics of pore structures across different shale lithofacies based on total organic carbon (TOC), X-ray ...
Yi Sun +3 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source