Results 71 to 80 of about 249,139 (224)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, Volume 20, Issue 6, Page 1494-1512, June 2026.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Experimental study on fractures quantitative characterization of shale during uniaxial compression

open access: yesFrontiers in Earth Science
IntroductionFractures are crucial to the development of shale oil and gas because they operate as a seepage pathway. The key to ensuring effective development is the fractures strong connection.
Liping Zhao, Hongjian Zhu
doaj   +1 more source

Holographic Subregion Complexity for Singular Surfaces

open access: yes, 2017
Recently holographic prescriptions are proposed to compute quantum complexity of a given state in the boundary theory. A specific proposal known as `holographic subregion complexity' is supposed to calculate the the complexity of a reduced density matrix
Bakhshaei, Elaheh   +2 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, Volume 20, Issue 6, Page 1473-1493, June 2026.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

The role of visibility as a predictor of children’s location choices in outdoor school grounds across age and gender

open access: yesFrontiers in Psychology
Children’s activities in school grounds are shaped by spatial design, affordances and social dynamics rather than preference alone. This study examines how children of different ages and gender use playground spaces, and how the design and visual depth ...
Mine Sak-Acur, Kerstin Sailer
doaj   +1 more source

Mixed Hodge Structures [PDF]

open access: yes, 2013
With a basic knowledge of cohomology theory, the background necessary to understand Hodge theory and polarization, Deligne's Mixed Hodge Structure on cohomology of complex algebraic varieties is described.Comment: pages ...
Elzein, Fouad, Trang, Lê Dung
core   +3 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

The spectrum of near-BPS Kerr-Newman black holes and the ABJM mass gap

open access: yesJournal of High Energy Physics
Supersymmetric rotating 1/16-BPS black holes in AdS 4 × S 7 are expected to capture the average degeneracy of BPS states in the dual ABJM superconformal theory for given fixed charges.
Matthew Heydeman, Chiara Toldo
doaj   +1 more source

Coastal public realms and housing livability in Saudi cities: developing a comprehensive waterfront development index (CWDI) for Jeddah

open access: yesFrontiers in Built Environment
IntroductionUrban waterfronts in Gulf cities are strategic public assets crucial for environmental risk management and enhancing the livability of surrounding residential and national housing areas, yet most existing urban evaluation indices are city ...
Ibrahim Hegazy, Ayman Imam
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

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