Results 71 to 80 of about 247,387 (224)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Universality and exactness of Schrodinger geometries in string and M-theory

, 2011
We propose an organizing principle for classifying and constructing Schrodinger-invariant solutions within string theory and M-theory, based on the idea that such solutions represent nonlinear completions of linearized vector and graviton Kaluza-Klein ...
A Adams, A Adams, A Adams, A Ceresole, A Ceresole, A Donos, A Donos, A Donos, A Donos, A Donos, CP Herzog, D Cassani, D Cassani, D Fabbri, D Orlando, DJ Gross, DT Son, E D’Hoker, E Elizalde, E Imeroni, E O Colgain, Eric Perlmutter, GT Horowitz, H Ooguri, HJ Kim, I Bena, J Boer de, J Hartong, J Jeong, J Maldacena, J Polchinski, JM Maldacena, JP Gauntlett, JP Gauntlett, JP Gauntlett, JP Gauntlett, JT Liu, K Balasubramanian, K Balasubramanian, K Skenderis, L Mazzucato, M Guica, M Günaydin, MB Green, MB Green, MF Paulos, MJ Duff, N Bobev, P Nieuwenhuizen van, Per Kraus, R Kallosh, RN Caldeira Costa, S Deger, S Haro de, SA Hartnoll, SS Gubser   +55 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Experimental study on fractures quantitative characterization of shale during uniaxial compression

Frontiers in Earth Science
IntroductionFractures are crucial to the development of shale oil and gas because they operate as a seepage pathway. The key to ensuring effective development is the fractures strong connection.
Liping Zhao, Hongjian Zhu
doaj   +1 more source

Edge and mixed metric dimension of Johnson graphs

In this paper, both edge and mixed metric dimensions of Johnson graphs $J_{n,k}$ are considered. A new tight lower bound for $β_E(J_{n,k})$ based on hitting sets has been obtained. Using this bound, exact values for $β_E(J_{n,2})$ and $β_M(J_{n,2})$ have been derived, and it is proved that $β_E(J_{n,2}) = β_M(J_{n,2})$.
Kratica, Jozef, Cangalović, Mirjana, Kovačević-Vujčić, Vera, Danas, Milica Milivojević   +3 more
openaire   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Coastal public realms and housing livability in Saudi cities: developing a comprehensive waterfront development index (CWDI) for Jeddah

Frontiers in Built Environment
IntroductionUrban waterfronts in Gulf cities are strategic public assets crucial for environmental risk management and enhancing the livability of surrounding residential and national housing areas, yet most existing urban evaluation indices are city ...
Ibrahim Hegazy, Ayman Imam
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The spectrum of near-BPS Kerr-Newman black holes and the ABJM mass gap

Journal of High Energy Physics
Supersymmetric rotating 1/16-BPS black holes in AdS 4 × S 7 are expected to capture the average degeneracy of BPS states in the dual ABJM superconformal theory for given fixed charges.
Matthew Heydeman, Chiara Toldo
doaj   +1 more source

Heat kernel estimates and their stabilities for symmetric jump processes with general mixed polynomial growths on metric measure spaces

, 2019
In this paper, we consider a symmetric pure jump Markov process $X$ on a general metric measure space that satisfies volume doubling conditions. We study estimates of the transition density $p(t,x,y)$ of $X$ and their stabilities when the jumping kernel ...
Bae, Joohak, Kang, Jaehoon, Kim, Panki, Lee, Jaehun   +3 more
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