Results 81 to 90 of about 394,923 (245)

Edge and mixed metric dimension of Johnson graphs

open access: yes
In this paper, both edge and mixed metric dimensions of Johnson graphs $J_{n,k}$ are considered. A new tight lower bound for $β_E(J_{n,k})$ based on hitting sets has been obtained. Using this bound, exact values for $β_E(J_{n,2})$ and $β_M(J_{n,2})$ have been derived, and it is proved that $β_E(J_{n,2}) = β_M(J_{n,2})$.
Kratica, Jozef   +3 more
openaire   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Some mixed Hodge structure on l^2-cohomology of covering of K\"ahler manifolds

open access: yes, 2013
We give methods to compute l^2-cohomology groups of a covering manifolds obtained by removing pullback of a (normal crossing) divisor to a covering of a compact K\"ahler manifold.
CP Rourke   +11 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Experimental study on fractures quantitative characterization of shale during uniaxial compression

open access: yesFrontiers in Earth Science
IntroductionFractures are crucial to the development of shale oil and gas because they operate as a seepage pathway. The key to ensuring effective development is the fractures strong connection.
Liping Zhao, Hongjian Zhu
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Reconstructing Quantum Geometry from Quantum Information: Area Renormalisation, Coarse-Graining and Entanglement on Spin Networks

open access: yes, 2006
After a brief review of spin networks and their interpretation as wave functions for the (space) geometry, we discuss the renormalisation of the area operator in loop quantum gravity.
Livine, Etera R., Terno, Daniel R.
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

The spectrum of near-BPS Kerr-Newman black holes and the ABJM mass gap

open access: yesJournal of High Energy Physics
Supersymmetric rotating 1/16-BPS black holes in AdS 4 × S 7 are expected to capture the average degeneracy of BPS states in the dual ABJM superconformal theory for given fixed charges.
Matthew Heydeman, Chiara Toldo
doaj   +1 more source

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