Results 51 to 60 of about 580,433 (262)

Nested mixed-mode oscillations

open access: yesPhysica D: Nonlinear Phenomena, 2020
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Inaba, Naohiko, Kousaka, Takuji
openaire   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

On the Relative Advantage of Mixed-Mode versus Single-Mode Surveys

open access: yesSurvey Research Methods, 2013
Survey researchers increasingly use mixed-mode surveys for general population data collection because mixed-mode surveys are argued to provide lower selection error at constant budgets or lower variable costs at constant selection error.
Jorre Vannieuwenhuyze
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Mixed Mode Oscillation in FitzHugh-Rinzel Model

open access: yesپژوهش‌های ریاضی, 2021
FitzHugh-Nagumo-Rinzel model is an important model for the dynamics of single neuron. We observed some patterns of Bursting specially Mixed Mode Oscillation (MMO) in this model.
Mohammad Reza Razvan   +1 more
doaj  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

A randomised trial and economic evaluation of the effect of response mode on response rate, response bias, and item non-response in a survey of doctors

open access: yesBMC Medical Research Methodology, 2011
Background Surveys of doctors are an important data collection method in health services research. Ways to improve response rates, minimise survey response bias and item non-response, within a given budget, have not previously been addressed in the same ...
Witt Julia   +6 more
doaj   +1 more source

[Multilingualism and Mixed-Mode Communication

open access: yes, 2023
Like other disciplines, the field of sociolinguistics is not a homogenous one. It rather comes in three “loosely connected waves” (Eckert 2012) with each wave applying specific sets of methods. How can we use methodological triangulation and combine these methods, both quantitative and qualitative in nature, to integrate the three waves of ...
openaire   +2 more sources

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

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