Results 61 to 70 of about 780,588 (296)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Health Supplier Quality and the Distribution of Child Health [PDF]

There is emerging evidence to suggest that initial differentials between the health of poor and more affluent children in the UK do not widen over early childhood. One reason may be that through the universal public funded health care system all children
Carol Propper, John A. Rigg, Simon Burgess   +2 more
core   +2 more sources

Garcinia drying using mixed-mode solar dryer technique: Drying kinetics, mathematical modeling and quality characteristics

Case Studies in Thermal Engineering
Fresh Garcinia, with a high MC at 725.9 ± 36.3 % d.b, requires a reduction in its MC for storage before processing. This study aimed to evaluate the drying kinetics, mathematical models, and quality of dried sliced Garcinia using MMSD.
Eleeyah Saniso, Lutfee Sueni, Muhammadkhoiri Hayibaka, Somakorn Chaiwarakorn, Abedeen Dasaesamoh, Huseng Chaidana   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Quality Characteristics of Rice Mash by Mixing Ratios of Rice and Rice Koji

Journal of the Korean Society of Food Science and Nutrition, 2013
The effects of Aspergillus oryzae rice koji (AO) and Asp. kawachii rice koji (AK) as enzyme preparations, on the quality characteristics of rice mash were invested in this study. The amount of AORM (Asp. oryzae rice mash) and AKRM (Asp. kawachii rice mash) were 50, 100, 200% (w/w) based on 100 g of rice.
Jin-Sook Kim, Ji-Hyun Lee, Young-Eun Chang, Gi-Chang Kim, Kyung-Mi Kim   +4 more
openaire   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Structural characteristics of hospitals and nurse-reported care quality, work environment, burnout and leaving intentions

Aim To investigate whether hospital characteristics not readily susceptible to change (i.e. hospital size, university status, and geographic location) are associated with specific self-reported nurse outcomes. Background Research often focuses on factors
Lindqvist, Rikard, Alenius, Lisa Smeds, Runesdotter, Sara, Tishelman, Carol, Griffiths, Peter   +4 more
core   +1 more source

Robust Design of Mixing Static and Dynamic Multiple Quality Characteristics

World Journal of Engineering and Technology, 2015
Increased market competition means that quality, cost and delivery time are crucial elements of modern production techniques. Taguchi’s robust design is the most powerful method available for reducing product cost, improving quality, and simultaneously reducing development time. Robust design aims to reduce the impact of noise on the product or process
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source