Results 71 to 80 of about 780,588 (296)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A Mixed-methods Systematic Review of Sleep Duration and Quality in Healthcare Workers: Impacts on Patient Safety and Quality of Care [PDF]

Objectives The aim of this systematic review was to synthesize evidence on the impacts of sleep duration and quality in healthcare workers on patient safety and quality of care.
Cha, Yu Jin, Martin, Priya, Cho, Daisy, McGrail, Matthew, Yi, Roy, Lu, Raymond Weimeng, Fox, Jordan   +6 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Characteristics of the Mixed Yogurt Fermented from Cow–Soy Milk in the Presence of Transglutaminase

Foods
The mixed yogurt was fermented from Cow–Soy milk and modified by transglutaminase (TG). The effects of mixed milk and TG on the quality characteristics of mixed yogurt were investigated by texture characteristics, rheology (rheometer) and structure ...
Xudong Lin, Zhiqi Cao, Jiaxin Zhang, Guangqing Mu, Shujuan Jiang   +4 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Incorporating generative conversational agents into collaborative argumentation: Do different customization strategies matter?

Educational Technology & Society
Collaborative argumentation allows groups to express, criticize, and integrate arguments to achieve the co-construction of collective knowledge. However, students often face challenges when proposing diversified arguments, gathering evidence, and ...
Xin Cui, Zhi-Qiang Ma, Xin-Ya You, Yuchen Chen, Jia-Jia Yao, Yun-Fang Tu
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Risk Evaluation for a Manufacturing Process Based on a Directed Weighted Network

Entropy, 2020
The quality of a manufacturing process can be represented by the complex coupling relationship between quality characteristics, which is defined by the directed weighted network to evaluate the risk of the manufacturing process.
Lixiang Wang, Wei Dai, Dongmei Sun, Yu Zhao   +3 more
doaj   +1 more source

Functional Properties of Wheat Gliadins. I. Effects on Mixing Characteristics and Bread Making Quality

Journal of Cereal Science, 2002
The effects of addition of total gliadin and gliadin subfractions on the 2 g Mixograph parameters and loaf volume data of cv. Hereward base flour were studied. The addition of increasing levels of total gliadin and gliadin subgroups to cv. Hereward base flour decreased the overall dough strength, as evidenced by decreases in the values for mixing time (
Khatkar, B. S., Fido, R. J., Tatham, A. S., Schofield, J. D.   +3 more
openaire   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source